槲皮素生物合成研究进展

孔 康翼1, 韩诚 武*1, 丁 玉萍1, 王 波1, 董 健微2
1、佳木斯大学生物与农业学院
2、佳木斯市农业技术推广中心

摘要


槲皮素作为一种具有重要生物活性的天然黄酮类化合物,在医药、食品、化妆品等多个领域展现出广阔的
应用前景。槲皮素的生物合成过程涉及复杂的代谢途径和精细的调控机制,对这一过程的深入研究不仅有助于提高
槲皮素的生物利用度,还将推动其在各领域的创新应用。本文系统梳理了近年来槲皮素生物合成领域的研究进展,
重点阐述了其生物合成途径、关键酶的功能特性以及代谢调控机制等方面的研究成果。同时,本文深入分析了当前
研究中存在的主要问题,并对未来研究方向进行了展望,为利用合成生物学策略实现槲皮素的高效生物合成奠定了
重要基础。

关键词


槲皮素;黄酮类化合物;生物合成;微生物

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参考


[1]Koopman F, Beekwilder J, Crimi B, van

Houwelingen A, Hall RD, Bosch D, van Maris AJ, Pronk JT,

Daran JM. De novo production of the flavonoid naringenin in

engineered Saccharomyces cerevisiae. Microb Cell Fact. 2012

Dec 8;11:155.

[2]Hwang EI, Kaneko M, Ohnishi Y, Horinouchi S.

Production of plant-specific flavanones by Escherichia coli

containing an artificial gene cluster. Appl Environ Microbiol.

2003 May;69(5):2699-706.

[3]Wu X, Liu J, Liu D, Yuwen M, Koffas MAG, Zha J.

Biosynthesis of eriodictyol from tyrosine by Corynebacterium

glutamicum. Microb Cell Fact. 2022 May 14;21(1):86. Park

SR, Paik JH, Ahn MS, Park JW, Yoon YJ. Biosynthesis

of plant-specific flavones and flavonols in Streptomyces

venezuelae. J Microbiol Biotechnol. 2010 Sep;20(9):1295-9.

[4]Park SR, Yoon JA, Paik JH, Park JW, Jung WS, Ban

YH, Kim EJ, Yoo YJ, Han AR, Yoon YJ. Engineering of

plant-specific phenylpropanoids biosynthesis in Streptomyces

venezuelae. J Biotechnol. 2009 May 20;141(3-4):181-8.

[5]Marín L, Gutiérrez-Del-Río I, Yagüe P, Manteca

Á, Villar CJ, Lombó F. De Novo Biosynthesis of Apigenin,

Luteolin, and Eriodictyol in the Actinomycete Streptomyces

albus and Production Improvement by Feeding and Spore

Conditioning. Front Microbiol. 2017 May 30;8:921.

[6]Álvarez-Álvarez R, Botas A, Albillos SM, Rumbero

A, Martín JF, Liras P. Molecular genetics of naringenin

biosynthesis, a typical plant secondary metabolite produced

by Streptomyces clavuligerus. Microb Cell Fact. 2015 Nov

9;14:178.

[7]Wu L, Li J, Liu T, Li S, Feng J, Yu Q, Zhang

J, Chen J, Zhou Y, Ji J, Chen K, Mao Y, Wang F, Dai

W, Fan X, Wu J, Guo C. Quercetin shows anti-tumor

effect in hepatocellular carcinoma LM3 cells by abrogating

JAK2/STAT3 signaling pathway. Cancer Med. 2019

Aug;8(10):4806-4820.

[8]Niazvand F, Orazizadeh M, Khorsandi L, Abbaspour

M, Mansouri E, Khodadadi A. Effects of Quercetin-Loaded

Nanoparticles on MCF-7 Human Breast Cancer Cells.

Medicina (Kaunas). 2019 Apr 22;55(4):114.

[9]Pham TND, Stempel S, Shields MA, Spaulding

C, Kumar K, Bentrem DJ, Matsangou M, Munshi HG.

Quercetin Enhances the Anti-Tumor Effects of BET

Inhibitors by Suppressing hnRNPA1. Int J Mol Sci. 2019 Sep

2;20(17):4293.

[10]Leonard E, Yan Y, Koffas MA. Functional expression

of a P450 flavonoid hydroxylase for the biosynthesis of plantspecific hydroxylated flavonols in Escherichia coli. Metab Eng.

2006 Mar;8(2):172-81.


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