微小RNA在银屑病免疫调节机制中的研究进展

赵 宗峰, 朱 　健, 陆 　晟, 吴秀 娟*
上海市徐汇区中心医院　皮肤科

摘要


银屑病是一种遗传与环境因素共同作用诱发的免疫介导的慢性、炎症性、免疫性、系统性疾病，其临床症
状表现为红斑、鳞屑性病变。microRNA是一种短的、非蛋白质编码的调节小RNA，在银屑病发病机制起重要作
用。微小RNA参与细胞增殖、分化、凋亡及器官形成和发育等多种生物学过程、参与机体免疫调节，并作为抑制或
降解靶信使RNA的转化因子。在银屑病中，microRNAs在基因水平发挥了重要的调控作用。为了深入了解银屑病中
microRNAs的生物学功能，查阅相关文献进行总结。

关键词


银屑病；miRNA；免疫调节

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