甲状腺素对白色脂肪棕色化影响的研究进展

高 淑珍1, 王 　叶2
1、青海大学
2、青海省人民医院内分泌科

摘要


脂肪组织在能量平衡和调节代谢中发挥着关键作用。肥胖的日益流行表明，目前基于饮食、运动和药理学
知识的策略不足以应对这一流行病。当前的研究重点是开发新的策略来增加机体能源消耗。随着研究的不断深入，
棕色脂肪组织（brown adipose tissue，BAT）通过以热的形式来释放能量，进一步消散脂肪的这一功能的发现，为肥
胖的治疗提供了新的思路，也引起了广泛研究。大量证据表明，甲状腺激素（TH）能够上调脂肪细胞线粒体内膜上
的解偶联蛋白1（uncoupling protein 1，UCP1）表达，从而诱导白色脂肪棕色化。甲状腺素对棕色脂肪细胞产热和消
耗能量有着巨大贡献，有利于维持机体能量代谢的稳态，从而改善肥胖和代谢综合征。然而引起白色脂肪棕色化过
程的具体机制还有待深入研究，以待为治疗肥胖等代谢类疾病提供理论依据。本文就甲状腺素对白色脂肪棕色化的
影响进行综述。

关键词


甲状腺素；白色脂肪棕色化；肥胖；棕色脂肪

全文:

PDF


参考


[1]Schirinzi V, Poli C, Berteotti C, Leone A. Browning

of Adipocytes: A Potential Therapeutic Approach to

Obesity. Nutrients. 2023; 15(9):2229.

[2]Jakab J, Miškić B, Mikšić Š, Juranić B, Ćosić V,

Schwarz D, Včev A. Adipogenesis as a Potential Anti-Obesity

Target: A Review of Pharmacological Treatment and Natural

Products. Diabetes Metab Syndr Obes. 2021 Jan 8;14:67-83.

[3](UCP1)Ikeda K, Yamada T. UCP1 Dependent and

Independent Thermogenesis in Brown and Beige Adipocytes.

Front Endocrinol (Lausanne). 2020 Jul 28;11:498.

[4]Mendoza A, Hollenberg AN. New insights

into thyroid hormone action. Pharmacol Ther. 2017

May;173:135-145.

[5]Alev Eroğlu Altınova, Beige Adipocyte as the Flame

of White Adipose Tissue: Regulation of Browning and

Impact of Obesity, The Journal of Clinical Endocrinology &

Metabolism, Volume 107, Issue 5, May 2022, Pages e1778–

e1788.

[6]Ikeda K, Yamada T. UCP1 Dependent and

Independent Thermogenesis in Brown and Beige Adipocytes.

Front Endocrinol (Lausanne). 2020 Jul 28;11:498.

[7]Schirinzi V, Poli C, Berteotti C, Leone A. Browning

of Adipocytes: A Potential Therapeutic Approach to

Obesity. Nutrients. 2023; 15(9):2229.

[8]Takeda Y, Harada Y, Yoshikawa T, Dai P.

Mitochondrial Energy Metabolism in the Regulation

of Thermogenic Brown Fats and Human Metabolic

Diseases. International Journal of Molecular Sciences. 2023;

24(2):1352.

[9]Yamauchi I, Sakane Y, Yamashita T, et al. Thyroid

hormone economy in mice overexpressing iodothyronine

deiodinases[J]. The FASEB Journal, 2022, 36(2): e22141.

[10]Negroiu CE, Tudorașcu I, Bezna CM, Godeanu

S, Diaconu M, Danoiu R, Danoiu S. Beyond the Cold:

Activating Brown Adipose Tissue as an Approach to Combat

Obesity. Journal of Clinical Medicine. 2024; 13(7):1973.

[11]Cioffi F, Giacco A, Goglia F, Silvestri E.

Bioenergetic Aspects of Mitochondrial Actions of Thyroid

Hormones. Cells. 2022; 11(6):997.

[12]Harb E, Kheder O, Poopalasingam G, et al. Brown

adipose tissue and regulation of human body weight[J].

Diabetes/Metabolism Research and Reviews, 2023, 39(1):

e3594.

[13]Petito G, Cioffi F, Magnacca N, et al. Adipose tissue

remodeling in obesity: an overview of the actions of thyroid

hormones and their derivatives[J]. Pharmaceuticals, 2023,

16(4): 572.

[14]Van Thi-Tuong Nguyen, Van Vu V, Van Pham

P. Brown adipocyte and browning thermogenesis: metabolic

crosstalk beyond mitochondrial limits and physiological

impacts[J]. Adipocyte, 2023, 12(1): 2237164.

[15]Liu S, Shen S, Yan Y, et al. Triiodothyronine (T3)

promotes brown fat hyperplasia via thyroid hormone receptor

α mediated adipocyte progenitor cell proliferation[J]. Nature

Communications, 2022, 13(1):3394.

[16] Zekri Y, Guyot R, Suñer I G, et al. Brown

adipocytes local response to thyroid hormone is required for

adaptive thermogenesis in adult male mice[J]. Elife, 2022, 11:

e81996.

[17]Tawfik I, Gottschalk B, Jarc A, et al. T3-induced

enhancement of mitochondrial Ca2+ uptake as a boost for

mitochondrial metabolism[J]. Free Radical Biology and

Medicine, 2022, 181: 197-208.

[18]Ma Y, Shen S, Yan Y, et al. Adipocyte Thyroid

Hormone β Receptor–Mediated Hormone Action Fine-tunes Intracellular Glucose and Lipid Metabolism and

Systemic Homeostasis[J]. Diabetes, 2023, 72(5): 562-574.

[19]Yau W W, Singh B K, Lesmana R, et al. Thyroid

hormone (T3) stimulates brown adipose tissue activation

via mitochondrial biogenesis and MTOR-mediated

mitophagy[J]. Autophagy, 2019, 15(1): 131-150.

[20]Ruiz-Ojeda FJ, Méndez-Gutiérrez A, Aguilera

CM, Plaza-Díaz J. Extracellular Matrix Remodeling of

Adipose Tissue in Obesity and Metabolic Diseases. Int J Mol

Sci. 2019 Oct 2;20(19):4888.

[21]Machado SA, Pasquarelli-do-Nascimento G,

da Silva DS, Farias GR, de Oliveira Santos I, Baptista

LB, Magalhães KG. Browning of the white adipose tissue

regulation: new insights into nutritional and metabolic

relevance in health and diseases. Nutr Metab (Lond). 2022

Sep 6;19(1):61.

[22]Schirinzi V, Poli C, Berteotti C, Leone A. Browning

of Adipocytes: A Potential Therapeutic Approach to Obesity.

Nutrients. 2023 May 8;15(9):2229.


Refbacks

  • 当前没有refback。