氨甲环酸不同给药途径治疗黄褐斑的研究进展

李 　思, 马 文宇
青海大学附属医院

摘要


黄褐斑是一种色素沉着过度和血管化的疾病，治疗困难，且易复发，会给患者造成相当大的心理负担。大
多数治疗的目的是减少黑素生成和黑素细胞侵袭的深度。目前治疗方法多样，氨甲环酸是一种超说明书用于治疗黄
褐斑的纤溶酶抑制剂，可以口服、局部、皮内注射及微针给药[1]。本文通过阐述氨甲环酸治疗黄褐斑不同给药途径
的相关治疗及疗效对比，旨在为治疗黄褐斑提供新思路。

关键词


黄褐斑；氨甲环酸；药物；激光；治疗

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参考


[1]Konisky, H, Balazic, E, Jaller, JA, et al. Tranexamic

acid in melasma: A focused review on drug administration

routes[J]. J Cosmet Dermatol, 2023; 22 (4): 1197-1206.

[2]Artzi O, Horovitz T, Bar-Ilan E, et al. The

pathogenesis of melasma and implications for treatment[J]. J

Cosmet Dermatol, 2021;20(11):3432-3445.

[3]Kim, KM, Lim, HW. The uses of tranexamic acid in

dermatology: a review[J]. Int J Dermatol, 2022; 62 (5): 589-598.

[4]Cardoso, R, Valente, R, Souza da Costa, CH, et al.

Analysis of Kojic Acid Derivatives as Competitive Inhibitors

of Tyrosinase: A Molecular Modeling Approach[J]. Molecules,

2021; 26 (10).

[5]Simpson, J, Peng, L, Ting, W. Evaluation of oral

tranexamic acid as a novel treatment for melasma with a

high benefit-risk ratio[J]. J Cosmet Dermatol, 2022; 21 (11):

6393-6399.

[6]Polat, Y, Saraç, G. Comparison of clinical results

of oral tranexamic acid and platelet rich plasma therapies in

melasma treatment[J]. Dermatol Ther, 2022; 35 (7): e15499.

[7]Wang, WJ, Wu, TY, Tu, YK, et al. The optimal

dose of oral tranexamic acid in melasma: A network meta-analysis[J]. Indian J Dermatol Ve, 2023; 89 (2): 189-194.

[8]Shihab, N, Prihartono, J, Tovar-Garza, A, et al.

Randomised, controlled, double-blind study of combination

therapy of oral tranexamic acid and topical hydroquinone in

the treatment of melasma[J]. Australas J Dermatol , 2020; 61

(3): 237-242.

[9]Martinez-Rico, JC, Chavez-Alvarez, S, Herz-Ruelas, ME, et al. Oral tranexamic acid with a triple

combination cream versus oral tranexamic acid monotherapy

in the treatment of severe melasma[J]. Cosmet Dermatol ,

2022; 21 (8): 3451-3457.

[10]Akl, EM. Liposomal azelaic acid 20% cream vs

hydroquinone 4% cream as adjuvant to oral tranexamic acid in

melasma: a comparative study[J]. J Dermatol Treat, 2021; 33

(4): 2008-2013.

[11]Lin, C, Zhu, X. Efficacy of photorejuvenation

combined with tranexamic acid and hydroquinone cream in

the treatment of complex facial pigmentation[J]. Medicine,

2023; 102 (34): e34556.

[12]Mahajan, VK, Patil, A, Blicharz, L, et al. Medical

therapies for melasma[J]. J Cosmet Dermatol-US, 2022; 21

(9): 3707-3728.

[13]Mahajan, VK, Patil, A, Blicharz, L, et al. Medical

therapies for melasma[J]. J Cosmet Dermatol-US, 2022; 21

(9): 3707-3728.

[14]Wang, JV, Christman, MP, Feng, H, et al. Laser-assisted delivery of tranexamic acid for melasma: Pilot study

using a novel 1927 nm fractional thulium fiber laser[J]. J

Cosmet Dermatol-US, 2020; 20 (1): 105-109.

[15]Park, SJ, Park, JW, Seo, SJ, et al. Evaluating the

tolerance and efficacy of laser-assisted delivery of tranexamic

acid, niacinamide, and kojic acid for melasma: A single center,

prospective, split-face trial[J]. Dermatol Ther, 2022; 35 (3):

e15287.

[16]Kaikati, J, El Bcherawi, N, Khater, JA, et al.

Combination Topical Tranexamic Acid and Vitamin C for

the Treatment of Refractory Melasma[J]. J Clin Aesthet

Dermatol, 2023; 16 (7): 63-65.

[17]Feng, X, Su, H, Xie, J. The efficacy and safety of

microneedling with topical tranexamic acid for melasma

treatment: A systematic review and meta-analysis[J]. J Cosmet

Dermatol-US, 2023; 23 (1): 33-43.

[18]Zaky, MS, Obaid, ZM, Khalil, EA, et al.

Microneedling-assisted topical tranexamic acid solution

versus 4% hydroquinone for treating melasma: A split-face

randomized study[J]. J Cosmet Dermatol-US, 2021; 20 (12):

4011-4016.

[19]Tawfic, SO, Abdel Hay, RM, Abouelazm, DI,

et al. Tranexamic Acid Microinjection Alone Versus Its

Combination With Fractional Carbon Dioxide Laser in

Melasma Treatment: A Dermoscopic Evaluation[J]. Dermatol

Surg, 2022; 48 (5): 556-561.

[20]Mehmood, M, Ali, M, Saleem, MA, et al.

Intradermal application of tranexamic acid (TA) as treatment

of melasma in the out-patients department of a public sector

hospital: A pilot study[J]. J Pak Med Assoc, 2022; 72 (11):

2275-2277.

[21]Hawwam, SA, Ismail, M, El-Attar, YA. Split-face comparative study between intradermal tranexamic acid

injection alone versus intradermal tranexamic acid injection

combined with Q-switched Nd:YAG laser in melasma

treatment: dermoscopic and clinical evaluation[J]. Laser Med

Sci, 2022; 37 (4): 2193-2201.

[22]Liang, R, Luo, H, Pan, W, et al. Comparative

efficacy and safety of tranexamic acid for melasma by different

administration methods: A systematic review and network

meta-analysis[J]. J Cosmet Dermatol-US, 2023; 23 (4):

1150-1164.


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