咖啡对肾癌与肾结石的影响

张 佳翔, 谷 欣权
吉林大学中日联谊医院

摘要


咖啡是全球最受欢迎和消费最广泛的饮料之一，因为它对中枢神经系统的刺激作用以及它的味道和香气。
咖啡是800多种挥发性化合物的复杂混合物，而咖啡因是其中的主要成分。在过去的几年里，由于其更广为人知的
药理学，咖啡逐渐转向对健康不那么负面的位置。例如，一杯咖啡中的咖啡因似乎通过拮抗腺苷受体来发挥其大
部分作用。流行病学研究和实验研究中的新方法表明，喝咖啡可能有助于预防几种慢性疾病，包括2型糖尿病和肝
病。大多数前瞻性队列研究并未发现咖啡消费与心血管疾病风险显著增加有关。还有证据表明，在某些方面，不
含咖啡因的咖啡可能具有与普通咖啡相似的好处，这表明除了咖啡因外，其他成分也有助于保护健康。对于饮用
适量咖啡（3–4杯/天，提供300–400毫克/天的咖啡因）的成年人，几乎没有健康风险的证据，但有一些健康益
处的证据[1]。值得一提的是已经有许多学者研究了咖啡与肾脏疾病的关联，本文简单介绍咖啡与肾结石及肾癌的
关联。

关键词


咖啡；肾癌；肾结石；分子机制

全文:

PDF


参考


[1]Nieber K. The Impact of Coffee on Health. Planta

Med. 2017 Nov;83(16):1256-1263. doi: 10.1055/s-0043-

115007. Epub 2017 Jul 4. PMID: 28675917.

[2]Barnela SR, Soni SS, Saboo SS, Bhansali AS. Medical

management of renal stone. Indian J Endocrinol Metab

2012;16:236–9.

[3]Knoll T, Buchholz N, Wendt-Nordahl G.

Extracorporeal shockwave lithotripsy vs. percutaneous

nephrolithotomy vs. flexible ureterorenoscopy for lower-pole

stones. Arab J Urol 2012;10:336–41.

[4]El Husseiny T, Buchholz N. The role of open stone

surgery. Arab J Urol 2012;10:284–8.

[5]Srisubat A, Potisat S, Lojanapiwat B, Setthawong V,

Laopaiboon M. Extracorporeal shock wave lithotripsy (ESWL)

versus percutaneous nephrolithotomy (PCNL) or retrograde

intrarenal surgery (RIRS) for kidney stones. Cochrane

Database Syst Rev 2009;CD007044.

[6]Ferraro P. M., Curhan G. C., D’Addessi A. &

Gambaro G. Risk of recurrence of idiopathic calcium kidney

stones: analysis of data from the literature. J Nephrol (2016).

[7]Hyams E. S. & Matlaga B. R. Economic impact of

urinary stones. Transl. Androl Urol. 3, 278–283 (2014).

[8]Peerapen P, Thongboonkerd V. Caffeine in

Kidney Stone Disease: Risk or Benefit? Adv Nutr. 2018 Jul

1;9(4):419-424. doi: 10.1093/advances/nmy016. PMID:

30032225; PMCID: PMC6054181.

[9]Kanlaya R., Singhto N. & Thongboonkerd V. EGCG

decreases binding of calcium oxalate monohydrate crystals

onto renal tubular cells via decreased surface expression of

alpha-enolase. J Biol. Inorg. Chem. 21, 339–346 (2016).

[10]Chutipongtanate S. & Thongboonkerd V. Phosphate

inhibits calcium oxalate crystal growth and crystallization

through reducing free calcium ions: a morphological analysis

and calcium consumption assay. Clin. Chem. Lab Med. 50,

1697–1698 (2012).

[11]Ferraro P. M., Taylor E. N., Gambaro G. & Curhan

G. C. Caffeine intake and the risk of kidney stones. Am. J

Clin. Nutr. 100, 1596–1603 (2014).

[12]Chutipongtanate S., Fong-ngern K., Peerapen P. &

Thongboonkerd V. High calcium enhances calcium oxalate

crystal binding capacity of renal tubular cells via increased

surface annexin A1 but impairs their proliferation and healing.

J Proteome. Res. 11, 3650–3663 (2012).

[13]Kanlaya R., Fong-ngern K. & Thongboonkerd V.

Cellular adaptive response of distal renal tubular cells to highoxalate environment highlights surface alpha-enolase as the

enhancer of calcium oxalate monohydrate crystal adhesion. J

Proteomics 80C, 55–65 (2013).

[14]Fong-ngern K., Sueksakit K. & Thongboonkerd V.

Surface heat shock protein 90 serves as a potential receptor for

calcium oxalate crystal on apical membrane of renal tubular

epithelial cells. J Biol. Inorg. Chem. 21, 463–474 (2016).

[15]Changtong C. et al. In vitro evidence of the

promoting effect of testosterone in kidney stone disease: A

proteomics approach and functional validation. J Proteomics

144, 11–22 (2016).

[16]Peerapen, P. and Thongboonkerd, V. Caffeine

prevents kidney stone formation by translocation of apical

surface annexin A1 crystal-binding protein into cytoplasm: In

vitro evidence. Sci. Rep. 6, 38536; doi: 10.1038/srep38536

(2016).

[17]Cirillo L, Innocenti S, Becherucci F. Global

epidemiology of kidney cancer. Nephrol Dial Transplant.

2024 May 31;39(6):920-928. doi: 10.1093/ndt/gfae036.

PMID: 38341277.

[18]Choi MJ, Park EJ, Oh JH, Min KJ, Yang ES, Kim

YH, Lee TJ, Kim SH, Choi YH, Park JW, Kwon TK.

Cafestol, a coffee-specific diterpene, induces apoptosis in

renal carcinoma Caki cells through down-regulation of

anti-apoptotic proteins and Akt phosphorylation. Chem

Biol Interact. 2011 Apr 25;190(2-3):102-8. doi: 10.1016/

j.cbi.2011.02.013. Epub 2011 Feb 18. PMID: 21334318.

[19]Van Dam RM, Feskens EJ. (2002) Coffee

consumption and risk of type 2 diabetes mellitus. Lancet. 360:

1477–8.

[20]Lee JE, Hunter DJ, Spiegelman D, et al. (2007)

Intakes of coffee, tea, milk, soda and juice and renal cell

cancer in a pooled analysis of 13 prospective studies. Int J

Cancer. 121: 2246–53.

[21]Ranheim T, Halvorsen B. Coffee consumption and

human health--beneficial or detrimental?--Mechanisms

for effects of coffee consumption on different risk factors

for cardiovascular disease and type 2 diabetes mellitus. Mol

Nutr Food Res. 2005 Mar;49(3):274-84. doi: 10.1002/

mnfr.200400109. PMID: 15704241.

[22]Nigra AD, Teodoro AJ, Gil GA. A Decade of

Research on Coffee as an Anticarcinogenic Beverage.

Oxid Med Cell Longev. 2021 Sep 15;2021:4420479. doi:

10.1155/2021/4420479. PMID: 34567408; PMCID:

PMC8460369.


Refbacks

  • 当前没有refback。