铜代谢在肺动脉高压中的作用研究进展
摘要
十分复杂，临床资料显示，PAH患者中金属离子常有异常，如铜离子、铁离子和锌离子等，由于金属离子是多种氧
化剂或抗氧化酶的辅助因子，因此，金属离子可能通过干扰细胞代谢参与PAH的发生，金属铜可通过参与促进氧化
应激、线粒体功能障碍、抑制蛋白酶体等过程介导细胞死亡从而在PAH的发病机制中发挥重要作用。在本文中，我
们综述了铜离子在细胞代谢、信号转导、以及铜异常引发的铜死亡在PAH发病机制中的作用，旨在为靶向铜死亡治
疗PAH提供一些新的思路。
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