细胞因在新型冠状病毒引发的细胞因子风暴中的研究进展 —— IL-2、IL-6、肿瘤坏死因子（TNF）
摘要
新冠肺炎中，机体为应对病毒感染而过度释放的细胞因子，称为“细胞因子风暴”，它正逐渐成为导致急性呼吸窘迫
综合征以及急性全身性器官功能损害的机制之一。免疫系统在防御和清除病毒方面起重要作用，且免疫功能的失调
可能导致新型冠状病毒肺炎（COVID-19）的快速进展。目前研究发现，患者疾病的发生、发展、恶化与体内细胞
因子风暴产生以及淋巴细胞亚群紊乱等免疫失衡机制密切相关。其中细胞免疫发挥了至关重要的作用。重症患者血液
中诸多炎症因子表达显著升高，主要是促炎细胞因子水平升高（称为细胞因子风暴）引发，如IL-2、IL-6、IL-8、肿
瘤坏死因子（TNF）等在COVID-19发病、病情演变以及预后方面的临床意义，有望早期通过预警细胞因子风暴及免
疫水平，早期及时治疗，预防危重症的形成，提高重症患者生存率，对改善预后和指导临床诊断工作提供理论依据。
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