八段锦联合rTMS治疗肝豆状核变性抑郁障碍的研究
摘要
将110例患者随机分为对照组（55例采用二巯丙磺酸钠治疗）和治疗组（55例采用联合治疗），共治疗8周。观察治
疗前后患者抑郁症状、情绪状态、生活质量、神经功能以及生理生化的变化。结果：干预8周后，两组患者HAMD
（P<0.05）、SAS（P<0.05）、中枢运动传导时间（P<0.01）、皮质潜伏期（P<0.01）均显著降低。治疗组的降低水平明
显低于对照组（P<0.001）。两组患者SF-36总分（P<0.05）和振幅（P<0.01）均显著升高，治疗组评分升高水平显
著高于对照组（P<0.001）。两组患者在治疗24h后尿铜含量均显著升高（P<0.05）。结论：联合治疗通过身心调控和
神经调控的协同作用，改善了患者的抑郁症状，提高了生活质量，值得临床推广。
关键词
全文:
PDF参考
[1]Coffey A J, Durkie M, Hague S, et al. A genetic study
of Wilson's disease in the United Kingdom [J]. Brain, 2013,
136(Pt 5): 1476-87.
[2]Bandmann O, Weiss K H, Kaler S G. Wilson's disease
and other neurological copper disorders [J]. Lancet Neurol,
2015, 14(1): 103-13.
[3]孙娟，马守亮，鲍远程.230例肝豆状核变性患者
的临床特征分析[J].中医药临床杂志，2024，36（05）：
934-8.
[4]Shribman S, Marjot T, Sharif A, et al. Investigation
and management of Wilson's disease: a practical guide from
the British Association for the Study of the Liver [J]. Lancet
Gastroenterol Hepatol, 2022, 7(6): 560-75.
[5]Camarata M A, Ala A, Coskun A K, et al. Major
Depressive Disorder in an International Multisite Wilson
Disease Registry [J]. J Acad Consult Liaison Psychiatry, 2023,
64(2): 106-17.
[6]EASL Clinical Practice Guidelines: Wilson's disease [J].
J Hepatol, 2012, 56(3): 671-85.
[7]Koh T C. Baduanjin -- an ancient Chinese exercise
[J]. Am J Chin Med, 1982, 10(1-4): 14-21.
[8]陆颖，赵晓霆，蒋婧，et al.八段锦干预抑郁、焦
虑的研究现状与思考[J].上海中医药杂志，2020，54（12）：
97-102.
[9]Zou L, Pan Z, Yeung A, et al. A Review Study on
the Beneficial Effects of Baduanjin [J]. J Altern Complement
Med, 2018, 24(4): 324-35.
[10]Luo X, Zhao M, Zhang Y, et al. Effects of baduanjin
exercise on blood glucose, depression and anxiety among
patients with type II diabetes and emotional disorders: A
meta-analysis [J]. Complement Ther Clin Pract, 2023, 50:
101702.
[11]Li K, Walczak-Kozłowska T, Lipowski M, et al.
The effect of the Baduanjin exercise on COVID-19-related
anxiety, psychological well-being and lower back pain of
college students during the pandemic [J]. BMC Sports Sci
Med Rehabil, 2022, 14(1): 102.
[12]Downar J, Blumberger D M, Daskalakis Z J.
Repetitive transcranial magnetic stimulation: an emerging
treatment for medication-resistant depression [J]. Cmaj, 2016,
188(16): 1175-7.
[13]Mcclintock S M, Reti I M, Carpenter L L, et al.
Consensus Recommendations for the Clinical Application of
Repetitive Transcranial Magnetic Stimulation (rTMS) in the
Treatment of Depression [J]. J Clin Psychiatry, 2018, 79(1).
[14]吴志英，王柠.中国肝豆状核变性诊治指南（修
订版）；proceedings of the中华医学会第十八次全国神经
病学学术会议，中国四川成都，F，2015[C].
[15]中国精神障碍分类与诊断标准第三版（精神障
碍分类）[J].中华精神科杂志，2001，（03）：59-63.
[16]Lefaucheur J P, Aleman A, Baeken C, et al.
Evidence-based guidelines on the therapeutic use of repetitive
transcranial magnetic stimulation (rTMS): An update (2014-
2018) [J]. Clin Neurophysiol, 2020, 131(2): 474-528.
[17]Chung S W, Hoy K E, Fitzgerald P B. Theta-burst
stimulation: a new form of TMS treatment for depression? [J].
Depress Anxiety, 2015, 32(3): 182-92.
[18]Zoicas I, Licht C, Mühle C, et al. Repetitive
transcranial magnetic stimulation (rTMS) for depressive-like
symptoms in rodent animal models [J]. Neurosci Biobehav
Rev, 2024, 162: 105726.
[19]Aleman A, Slotema C W, Sommer I E. rTMS
deserves a fair chance as a novel treatment for depression [J].
Acta Psychiatr Scand, 2014, 130(5): 324-5.
[20]伍永慧，陈偶英，罗尧岳，等.太极拳和八段锦
在改善冠心病病人焦虑、抑郁情绪中的应用[J].护理研
究，2016，30（32）：4050-2.
Refbacks
- 当前没有refback。
