转移前微环境在乳腺癌肺转移中的相关机制研究进展

李 翊, 沈 国双, 李 自涛, 周 雪莹, 崔 家咏
青海大学附属肿瘤医院

摘要


乳腺癌目前仍然是全球发病率最高，病情严重的疾病之一，远处肿瘤转移也往往将导致这些患者的最终癌
症死亡。而血管远处细胞转移也是另外一个同样非常复杂重要的生理过程，其中血管转移的前体微生态环境因子
（pre-metastatic niches，PMNs）则是一个极其重要的生物环节因子之一，主要影响包括了血管外渗漏、通透性的增强、
基质细胞的激活、细浆胞外基质体（extracellular matrix，ECM）功能的重塑以及免疫功能细胞的募集等。远处转移
最常见部位为肺组织，越来越多的学者开始详细地探究乳腺癌肺PMN形成的机制。目前未进行系统总结，本综述通
过检索相关文献系统阐述肺PMN的变化，旨在为乳腺癌的肺转移治疗提供更多的临床依据。

关键词


肺转移前微环境；乳腺癌；迁移；定植；机制

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参考


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