皮肤菌群与雌激素受体阴性乳腺癌风险的关系： 两样本孟德尔随机化研究

郭 坤, 柴 盛钧, 王晓 武*
青海大学附属医院肿瘤外科

摘要


目的：本研究通过两样本孟德尔随机化方法探讨皮肤菌群与乳腺癌之间的因果关系。方法：利用大规模基
因组关联研究（GWAS）数据，精选工具变量SNPs，并基于孟德尔随机化假设进行分析。采用逆方差加权（IVW）
法、MR-Egger回归及加权中位数法等研究方法深入探究两者的因果联系。结果：分析显示8种皮肤菌群与ER-乳
腺癌风险显著相关，如asv093增加ER-乳腺癌的发病风险，asv031降低ER-乳腺癌的发病风险。敏感性分析结果也
证明该结论的可靠性，未发现显著异质性或多效性。结论：本研究首次从遗传学角度揭示皮肤菌群与乳腺癌之间存
在的潜在因果关系，为深入探讨乳腺癌发病机制及未来预防和治疗策略提供新的思路。

关键词


乳腺癌；孟德尔随机化；皮肤菌群；SNP

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参考


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补充图1 皮肤菌群孟德尔随机分析的散点图

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