腹腔热灌注化疗在进展期胃癌的研究进展

马 进福1, 张 成武2
1、青海大学
2、青海大学;青海大学附属医院

摘要


胃癌是全球发病率排名第五的恶性肿瘤,胃癌具有预后差,复发率高,死亡率高的特点。现如今,腹腔热
灌注化疗在治疗进展期胃癌患者中扮演着重要的角色,主要为预防性和治疗性两种应用方向。本文主要探讨了腹腔
热灌注化疗在进展期胃癌治疗中的研究进展。首先,介绍了腹腔热灌注化疗的相关研究,包括HIPEC的原理、发展
及安全性。然后,详细阐述了腹腔热灌注化疗在进展期胃癌治疗中的应用,包括治疗性和预防性HIPEC的有效性。
最后,总结了腹腔热灌注化疗在进展期胃癌治疗中的优势和未来研究方向。

关键词


腹腔热灌注化疗;进展期胃癌;研究进展

全文:

PDF


参考


[1]S. Murata, H. Naito et al.“Phase II trial of adjuvant

hyperthermic intraperitoneal chemotherapy with three drugs

for the prophylactic treatment of carcinomatosis after resection

of advanced gastric cancer..”Journal of Clinical Oncology

(2009). e15588.

[2]S. Nikolić, M. Žegarac et al.“Ultraradical surgery and

heated intraperitoneal chemotherapy (HIPEC) as multimodal

treatment of advanced colorectal cancer..”Journal of Clinical

Oncology (2011). 585.

[3]R. Yarema, M. Ohorchak et al.“Hyperthermic

intraperitoneal chemotherapy (HIPEC) in combined treatment

of locally advanced and disseminated gastric cancer: Results of

a single-centre study..”Annals of Oncology (2018). v24 .

[4]Spratt A. Brandl, Y. Yonemura et al.“Long-term

survival in patients with peritoneal metastasized gastric cancer

treated with cytoreductive surgery and HIPEC: A multi_xfffe_institutional cohort from PSOGI..”(2020). 390-390.

[5]张涛,曲直,王贇等.腹腔热灌注化疗的研究进

展 [J].现代肿瘤医学,2022,30(05):930-935.

[6]魏志刚,卿三华.腹腔热灌注化疗治疗胃肠癌 [J].

103

现代医学前沿 | 第2卷/第11期

Advances in Mordern Medical

世界华人消化杂志,2006(02):134-137.

[7]陈新华,罗俊,刘浩等.腹腔热灌注化疗预防局

部进展期胃癌根治术后腹膜复发的研究进展 [J].中华胃肠

外科杂志,2018,21(05):593-599.

[8]姬忠贺,刘刚,安松林等.完全肿瘤细胞减灭术

加腹腔热灌注化疗治疗胃癌腹膜转移的病例筛选策略 [J].

中国肿瘤临床,2020,47(03):128-134.

[9]杨立涛,杜义安.腹腔热灌注化疗在胃癌腹膜转移

治疗中的作用 [J].中国肿瘤,2016,25(05):380-385.

[10]王大广,邢雁鹏,国瑀辰等.腹腔热灌注化疗联

合全身新辅助静脉化疗对胃癌腹膜转移患者的疗效研究

[J].中华胃肠外科杂志,2016,19(05):540-544.

[11]廖锡群,卢红梅,吴小肖.腹腔热灌注化疗与护

理治疗进展期胃癌及结肠癌的临床疗效分析 [J].护理实践

与研究,2017,14(23):11-12.

[12]陈新华,罗俊,刘浩等.腹腔热灌注化疗预防局

部进展期胃癌根治术后腹膜复发的研究进展 [J].中华胃肠

外科杂志,2018,21(05):593-599.

[13]姬忠贺,刘刚,安松林等.完全肿瘤细胞减灭术

加腹腔热灌注化疗治疗胃癌腹膜转移的病例筛选策略 [J].

中国肿瘤临床,2020,47(03):128-134.

[14]朱正纲.腹腔与全身性联合新辅助化疗治疗胃癌

腹膜转移的初步效果 [J].中华普通外科学文献(电子版),

2021,15(01):42.

[15]Fujimoto.“Peritonealkarzinose: HIPEC ohne

Zusatznutzen.”Zeitschrift für Gastroenterologie - German

Journal of Gastroenterology(2021).

[16]王红,汪海岩,李勇威等.腹腔灌注联合静脉、

口服三途径化学治疗胃癌腹膜转移的效果分析 [J].中国综

合临床,2020,36(05):449-454.

[17]Jafari A. Mcree and B. O'Neil.“The Role of

HIPEC in Gastrointestinal Malignancies: Controversies and

Conclusions..”Oncology (2015). 523-4, C3 .

[18]席孝忠.全身新辅助静脉化疗结合腹腔热灌注化

疗治疗胃癌腹膜转移患者的效果评价 [J].现代诊断与治

疗,2019,30(15):2629-2631.

[19]王子康,刘标,许戈良.结直肠吻合口漏的危险

因素、发生机制及治疗方案研究现状 [J].结直肠肛门外

科,2018,24(05):527-532.

[20]夏孝垚.结直肠术后吻合口瘘危险因素的meta分

析 [D].南昌大学,2019.

[21]Jacopo Desiderio, S. van Ruth et al.“Randomized

trial of cytoreduction and hyperthermic intraperitoneal

chemotherapy versus systemic chemotherapy and palliative

surgery in patients with peritoneal carcinomatosis of colorectal

cancer..”Journal of Clinical Oncology(2003).

[22]Z. Ji, Kai-Wen Peng et al.“Current status and

future prospects of clinical trials on CRS + HIPEC for

gastric cancer peritoneal metastases.”International Journal of

Hyperthermia (2017). 562 - 570.

[23]Anish J Jain and B. Badgwell.“Current Evidence

for the Use of HIPEC and Cytoreductive Surgery in Gastric

Cancer Metastatic to the Peritoneum.”Journal of Clinical

Medicine (2023).

[24]李雁,周云峰,谢丛华等.细胞减灭术加腹腔热

灌注化疗治疗胃癌腹膜转移癌的临床研究 [J].中国肿瘤临

床,2012,39(22):1734-1740.

[25]V. Verwaal.“Long-Term Results of Cytoreduction

and HIPEC Followed by Systemic Chemotherapy.”Cancer

Journal (2009). 212-215.

[26]A. Brandl, Y. Yonemura et al.“Long-term survival

in patients with peritoneal metastasized gastric cancer treated

with cytoreductive surgery and HIPEC: A multi-institutional

cohort from PSOGI..”(2020). 390-390.

[27]Koga. Privalov, Andrey Vazenin et al.“HIPEC in

treatment of gastric cancer with high risk of carcinomatosis:

Russians Regional Centre experience..”(2017).

[28 ]B. R au, M. Loeffle r et al.“Pe riope r ative

chemotherapy and cytoreductive surgery with versus without

HIPEC in gastric cancer with limited peritoneal metastases: A

randomized phase III study (GASTRIPEC)..”(2015).

[29]Anish J Jain and B. Badgwell.“Current Evidence

for the Use of HIPEC and Cytoreductive Surgery in Gastric

Cancer Metastatic to the Peritoneum.”Journal of Clinical

Medicine (2023).

[30]Kaibara, A. Cappellani et al.“The role of HIPEC in

the treatment of peritoneal carcinomatosis from gastric cancer:

between lights and shadows.”Anti-Cancer Drugs (2015).

123-138.

[31]詹宏杰,梁寒,王宝贵,et al.进展期胃癌术中

腹腔热灌注化疗的预后分析 [J].中国肿瘤临床,2012,39

(22):1730-1733.

[32]Selin Akturk Esen, Y. M. Ozgun et al.“Neoadjuvant

Chemotherapy Followed by Cytoreductive Surgery and

HIPEC Improves Survival in Peritoneal Metastatic Gastric

Cancer.”Oncology (2023). 321 - 327.


Refbacks

  • 当前没有refback。