肝门部胆管癌淋巴结廓清的争议与进展
摘要
于可切除疾病的患者,根治性切除术是肝门部胆管癌患者唯一可能治愈的治疗方法。肝门部胆管癌的预后通常较差,
准确的预后至关重要。淋巴结转移是肿瘤预后的重要指标。在文献中,有关肝门部胆管癌淋巴结清扫方面仍然存在
争议。目前,主要的争议点包括合理的淋巴结清扫范围、获取的最少淋巴结数量和最佳的预后评估指标。笔者基于
当前最新发表文献探讨这些争议,从而对肝门部胆管癌淋巴结廓清正确认识和理解,规范化肝门部胆管癌的淋巴结
清扫,改善患者预后。
关键词
全文:
PDF参考
[1]中华医学会外科学分会胆道外科学组,解放军全
军肝胆外科专业委员会,肝门部胆管癌诊断和治疗指南
(2013版)[J].中华外科杂志,2013,51(10):865-871.
[2]B X, W Z, J C, et al. - Comparative study on left_xfffe_sided versus right-sided hepatectomy for resectable [J]. World
J Surg Oncol, 2023, 21(1): 023-03037.
[3]FS D, M A, N S, et al. - Outcomes after Surgical
Resection of Hilar Cholangiocarcinoma [J]. J Coll Physicians
Surg Pak, 2019, 29(9): 874-7.
[4]B L, ID- ORCID X, Z L, et al. - Surgical treatment
of hilar cholangiocarcinoma: retrospective analysis [J]. BJS
Open, 2023, 7(3):
[5]HENG G, HUANG B, SHEN Y, et al. Vascular
invasion and lymph node metastasis mediate the effect of
CA242 on prognosis in hilar cholangiocarcinoma patients after
radical resection [J]. Frontiers in oncology, 2022, 12(1071439.
[ 6 ] G U A N J F , W A N G K . [ C u r r e n t s t a t u s
of intraoperative lymph node dissection for hilar
cholangiocarcinoma] [J]. Zhonghua wai ke za zhi [Chinese
journal of surgery], 2020, 58(1): 48-51.
[7]F G, F A, A G, et al. - Association of Lymph Node
Status With Survival in Patients After Liver Resection [J].
JAMA Surg, 2016, 151(10): 916-22.
[8]S C, A R, M S, et al. - What is the most accurate
lymph node staging method for perihilar [J]. European journal
of surgical oncology : the journal of the European Society
of Surgical Oncology and the British Association of Surgical
Oncology, 2017, 43(4): 743-50.
[9 ]DEOL IVE IRA M L, CUNN INGHAM S C,
CAMERON J L, et al. Cholangiocarcinoma: thirty-one_xfffe_year experience with 564 patients at a single institution [J].
Annals of surgery, 2007, 245(5): 755-62.
[10]SONG S C, CHOI D W, KOW A W, et al. Surgical
outcomes of 230 resected hilar cholangiocarcinoma in a single
centre [J]. ANZ journal of surgery, 2013, 83(4): 268-74.
[11]FURUSAWA N, KOBAYASHI A, YOKOYAMA
T, et al. Surgical treatment of 144 cases of hilar
cholangiocarcinoma without liver-related mortality [J]. World
journal of surgery, 2014, 38(5): 1164-76.
[12]International Union Against Cancer (UICC)
TNM classification of malignant tumours 7th ed Sobin
LH, Gospodarowicz MK, Wittekind C, editors Chichester:
Wiley-Blackwell; 2010,
[13]Amin MB, Edge S,Greene F, et al , American Joint
Committee on Cancer (AJCC) Cancer Staging Manual 8th ed
New York: Springer, 2017,
[14]周燕,刘宇,魏玲玲,et al.扩大淋巴结清扫对
腹腔镜下肝门胆管癌根治术患者临床预后的随访研究 [J].
中国医学前沿杂志(电子版),2021,13(10):135-8.
[15]HAKEEM A R, MARANGONI G, CHAPMAN
S J, et al. Does the extent of lymphadenectomy, number of
lymph nodes, positive lymph node ratio and neutrophil_xfffe_lymphocyte ratio impact surgical outcome of perihilar
cholangiocarcinoma? [J]. Eur J Gastroenterol Hepatol, 2014,
26(9): 1047-54.
[16]Y K, M N, J K, et al. - Lymph node metastasis
from hilar cholangiocarcinoma: audit of 110 patients who [J].
Annals of surgery, 2001, 233(3): 385-92.
[17 ]HE M, XU X, FENG H, et al. Regi o n al
lymphadenectomy vs. extended lymphadenectomy for hilar
cholangiocarcinoma (Relay-HC trial): study protocol for
a prospective, multicenter, randomized controlled trial [J].
Trials, 2019, 20(1): 528.
[18]BERGQUIST A, VON SETH E. Epidemiology
of cholangiocarcinoma [J]. Best practice & research Clinical
129
现代医学前沿 | 第2卷/第11期
Advances in Mordern Medical
gastroenterology, 2015, 29(2): 221-32.
[19]VALERO V, 3RD, COSGROVE D, HERMAN
J M, et al. Management of perihilar cholangiocarcinoma
in the era of multimodal therapy [J]. Expert review of
gastroenterology & hepatology, 2012, 6(4): 481-95.
[20]SCHWARZ R E, SMITH D D. Lymph node
dissection impact on staging and survival of extrahepatic
cholangiocarcinomas, based on U.S. population data [J]. J
Gastrointest Surg, 2007, 11(2): 158-65.
[21 ]MAO K, LIU J, SUN J, et al. Pattern s and
prognostic value of lymph node dissection for resected
perihilar cholangiocarcinoma [J]. Journal of gastroenterology
and hepatology, 2016, 31(2): 417-26.
[ 2 2 ] K A M B A K A M B A P , L I N E C K E R M ,
SLANKAMENAC K, et al. Lymph node dissection in
resectable perihilar cholangiocarcinoma: a systematic review
[J]. American journal of surgery, 2015, 210(4): 694-701.
[23]ROCHA F G, MATSUO K, BLUMGART L H, et
al. Hilar cholangiocarcinoma: the Memorial Sloan-Kettering
Cancer Center experience [J]. J Hepatobiliary Pancreat Sci,
2010, 17(4): 490-6.
[24]ITO K, ITO H, ALLEN P J, et al. Adequate lymph
node assessment for extrahepatic bile duct adenocarcinoma [J].
Annals of surgery, 2010, 251(4): 675-81.
[25]GIULIANTE F, ARDITO F, GUGLIELMI A,
et al. Association of Lymph Node Status With Survival in
Patients After Liver Resection for Hilar Cholangiocarcinoma
in an Italian Multicenter Analysis [J]. JAMA Surg, 2016,
151(10): 916-22.
[26]AOBA T, EBATA T, YOKOYAMA Y, et al.
Assessment of nodal status for perihilar cholangiocarcinoma:
location, number, or ratio of involved nodes [J]. Annals of
surgery, 2013, 257(4): 718-25.
[27]Edge S,Byrd D,Compton CC,et alAmerican Joint
Committee on Cancer(AJCC) Cancer Staging Manual7th
edNew York:Spring,2010,
[28]Amin MB, Edge S,Greene F, et al , American Joint
Committee on Cancer (AJCC) Cancer Staging Manual 8th ed
New York: Springer, 2017,
[29]BERTERO L, MASSA F, METOVIC J, et al.
Eighth Edition of the UICC Classification of Malignant
Tumours: an overview of the changes in the pathological
TNM classification criteria-What has changed and why? [J].
Virchows Arch, 2018, 472(4): 519-31.
[30]L B, ID O, F M, et al. - Eighth Edition of the
UICC Classification of Malignant Tumours: an overview of
[J]. Virchows Arch, 2018, 472(4): 519-31.
[31]SAKATA J, TAKIZAWA K, MIURA K, et al.
Rational Extent of Regional Lymphadenectomy and the
Prognostic Impact of the Number of Positive Lymph Nodes
for Perihilar Cholangiocarcinoma [J]. Annals of surgical
oncology, 2023, 30(7): 4306-17.
[32]LIU Z P, ZHANG Q Y, CHEN W Y, et al.
Evaluation of Four Lymph Node Classifications for the
Prediction of Survival in Hilar Cholangiocarcinoma [J]. J
Gastrointest Surg, 2022, 26(5): 1030-40.
[33]T A, T E, Y Y, et al. - Assessment of nodal status
for perihilar cholangiocarcinoma: location, number, or [J].
Annals of surgery, 2013, 257(4): 718-25.
[34]A G, A R, T C, et al. - Prognostic significance of
lymph node ratio after resection of peri-hilar [J]. Hpb, 2011,
13(4): 240-5.
[35]K M, J L, J S, et al. - Patterns and prognostic value
of lymph node dissection for resected perihilar [J]. Journal of
gastroenterology and hepatology, 2016, 31(2): 417-26.
[36 ]SPOLVERATO G, E JAZ A, KIM Y, et al.
Prognostic Performance of Different Lymph Node Staging
Systems After Curative Intent Resection for Gastric
Adenocarcinoma [J]. Annals of surgery, 2015, 262(6): 991-8.
[ 3 7 ] G U G L I E L M I A , R U Z Z E N E N T E A ,
BERTUZZO F, et al. Assessment of nodal status for perihilar
cholangiocarcinoma location, number, or ratio of involved
nodes [J]. Hepatobiliary surgery and nutrition, 2013, 2(5):
281-3.
[38]AURELLO P, PETRUCCIANI N, NIGRI G R, et
al. Log odds of positive lymph nodes (LODDS): what are their
role in the prognostic assessment of gastric adenocarcinoma? [J].
J Gastrointest Surg, 2014, 18(7): 1254-60.
[39]ZHOU R, ZHANG J, SUN H, et al. Comparison
of three lymph node classifications for survival prediction in
distant metastatic gastric cancer [J]. International journal of
surgery (London, England), 2016, 35(165-71.
[40]BAGANTE F, TRAN T, SPOLVERATO G, et al.
Perihilar Cholangiocarcinoma: Number of Nodes Examined
and Optimal Lymph Node Prognostic Scheme [J]. J Am Coll
Surg, 2016, 222(5): 750-9.e2.
Refbacks
- 当前没有refback。