白介素-18细胞因子的生物学作用

李 金杰, 马 婕*
青海大学附属医院(临床医学院)

摘要


白细胞介素-18(interleukin-18,IL-18)是一种强效的促炎性细胞因子,参与宿主对感染的防御,并调节
先天和获得性免疫反应。IL-18由造血细胞和非造血细胞产生,包括单核细胞、巨噬细胞、角质形成细胞和间充质细
胞。IL-18可潜在地诱导炎症和细胞毒性免疫细胞活性,导致自身免疫。本文就IL-18在炎症和免疫中的生物学特性
及其诱导、调节和治疗进行综述。

关键词


IL-18;IL-18受体;IL-18结合蛋白;单克隆抗体

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参考


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