良性前列腺增生治疗的研究进展

马 麟, 陈 国俊, 武 玲玲
青海大学附属医院

摘要


良性前列腺增生(BPH)被定义为一种组织学诊断,是指平滑肌和上皮细胞在前列腺移行区内增殖前列腺
移行区约占前列腺的5%,是围绕近端尿道的部分。该区域组织持续生长常常伴随男性一生。老年男性BPH的发生与
下尿路梗阻症状(LUTS)密切相关,下尿路症状由多种症状定义,包括尿急、夜尿、尿频、排尿困难、排尿困难、
排尿困难以及排尿时尿流微弱或中断。尽管一些LUTS被定义为“独立于BPH的LUTS”,但BPH及其下游影响导致
许多男性出现慢性LUTS。本文对现有治疗良性前列腺增生的不同治疗方式进行综述。

关键词


良性前列腺增生;下尿路梗阻;药物治疗;手术治疗

全文:

PDF


参考


[1]Oelke M, Bachmann A, Descazeaud A, et al. EAU

Guidelines on the Treatment and Follow-up of Nonneurogenic Male Lower Urinary Tract Symptoms Including

Benign Prostatic Obstruction[J]. European Urology, 2013,

64(1): 118-140.

[2]Cho A, Chughtai B, Te A E. Benign Prostatic

Hyperplasia and Male Lower Urinary Tract Symptoms:

Epidemiology and Risk Factors[J]. Current Bladder

Dysfunction Reports, 2020, 15(2): 60-65.

[3]Aaron L, Franco O E, Hayward S W. Review of

Prostate Anatomy and Embryology and the Etiology of

Benign Prostatic Hyperplasia[J]. Urologic Clinics of North

America, 2016, 43(3): 279-288.

[4]An J, Kong H. c c[J]. PLOS ONE, 2022, 17(5):

e0268695.

[5]Liu C C, Huang S P, Li W M, et al. Relationship

Between Serum Testosterone and Measures of Benign

Prostatic Hyperplasia in Aging Men[J]. Urology, 2007, 70(4):

677-680.

[6]The management of lower urinary tract symptoms in

men - Bohrium[EB].

[7]Lerner L B, McVary K T, Barry M J, et al.

Management of Lower Urinary Tract Symptoms Attributed

to Benign Prostatic Hyperplasia: AUA Guideline Part II—

Surgical Evaluation and Treatment[J]. Journal of Urology,

2021, 206(4): 818-826.

[8]Franco J V, Garegnani L, Liquitay C M E, et al.

Transurethral microwave thermotherapy for the treatment of

lower urinary tract symptoms in men with benign prostatic

hyperplasia[J]. Cochrane Database of Systematic Reviews,

2021(6).

[9]Chee K C H, Ibrahim M F, Md Z Z. A prospective,

randomized clinical trial comparing bipolar plasma kinetic

resection of the prostate versus conventional monopolar

transurethral resection of the prostate in the treatment of

benign prostatic hyperplasia[J]. Annals of Saudi Medicine,

2009, 29(6): 429-432.

[10]Efficacy and safety of prostatic artery embolization

for benign prostatic hyperplasia: A systematic review and

meta-analysis of randomized controlled trials - Bohrium[EB].

[11]Herschorn S, Jones J S, Oelke M, et al. Efficacy and

Tolerability of Fesoterodine in Men With Overactive Bladder:

A Pooled Analysis of 2 Phase III Studies[J]. Urology, 2010,

75(5): 1149-1155.

[12]Schaefer W. Re: Safety and Tolerability of

Tolterodine for the Treatment of Overactive Bladder in Men

With Bladder Outlet Obstruction: P. Abrams, S. Kaplan, H.

J. De Koning Gans and R. Millard J Urol, 175: 999–1004,

2006[J]. Journal of Urology, 2006, 176(5): 2311-2313.

[13]Khullar V, Amarenco G, Angulo J C, et al. Efficacy

and Tolerability of Mirabegron, a β3-Adrenoceptor

Agonist, in Patients with Overactive Bladder: Results from a

Randomised European–Australian Phase 3 Trial[J]. European

Urology, 2013, 63(2): 283-295.

[14]Chapple C R, Kaplan S A, Mitcheson D, et al.

Randomized Double-blind, Active-controlled Phase 3

Study to Assess 12-Month Safety and Efficacy of Mirabegron,

a β3-Adrenoceptor Agonist, in Overactive Bladder[J].

European Urology, 2013, 63(2): 296-305.

[15]Yamaguchi O, Kakizaki H, Homma Y, et al.

Solifenacin as Add-on Therapy for Overactive Bladder

Symptoms in Men Treated for Lower Urinary Tract

Symptoms— ASSIST, Randomized Controlled Study[J].

Urology, 2011, 78(1): 126-133.

[16]Kaplan S A, Lee J Y, Meehan A G, et al. TimeCourse of Incident Adverse Experiences Associated with

Doxazosin, Finasteride and Combination Therapy in Men

with Benign Prostatic Hyperplasia: The MTOPS Trial[J]. The

Journal of Urology, 2016, 195(6): 1825-1829.

[17]Kim H J, Sun H Y, Choi H, et al. Efficacy and

Safety of Initial Combination Treatment of an Alpha Blocker

with an Anticholinergic Medication in Benign Prostatic

Hyperplasia Patients with Lower Urinary Tract Symptoms:

Updated Meta-Analysis[J]. PLoS One, 2017.

[18]Wagg A, Staskin D, Engel E, et al. Efficacy, safety,

and tolerability of mirabegron in patients aged ≥ 65 yr

with overactive bladder wet: a phase IV, double-blind,

randomised, placebo-controlled study (PILLAR)[J]. European

Urology, 2020, 77(2): 211-220.

[19]Liu Y, Lu J, Xiao C, et al. Impact on Sexual Function

of Endoscopic Enucleation Versus Transurethral Resection

of the Prostate for Lower Urinary Tract Symptoms Due to

Benign Prostatic Hyperplasia: A Systematic Review and MetaAnalysis[J]. Journal of endourology, 2020, 203(10): E492.

[20]Sakalis V I, Karavitakis M, Bedretdinova D,et al.

Medical Treatment of Nocturia in Men with Lower Urinary

Tract Symptoms: Systematic Review by the European

Association of Urology Guidelines Panel for Male Lower

Urinary Tract Symptoms[J]. European Urology, 2017, 72(5):

757-769.

[21]Roehrborn C G, Siami P, Barkin J, et al. The Effects

of Combination Therapy with Dutasteride and Tamsulosin

on Clinical Outcomes in Men with Symptomatic Benign

Prostatic Hyperplasia: 4-Year Results from the CombAT

Study[J]. European Urology, 2010, 57(1): 123-131.

[22]Allison S J, Gibson W. Mirabegron, alone and in

combination, in the treatment of overactive bladder: realworld evidence and experience[J]. Therapeutic Advances in

Urology, 2018, 10(12): 411-419.

[23]Van Kerrebroeck P, Chapple C, Drogendijk T, et al.

Combination Therapy with Solifenacin and Tamsulosin Oral

Controlled Absorption System in a Single Tablet for Lower

Urinary Tract Symptoms in Men: Efficacy and Safety Results

from the Randomised Controlled NEPTUNE Trial[J].

European Urology, 2013, 64(6): 1003-1012.

[24]Tolterodine and tamsulosin for treatment of men

with lower urinary tract symptoms and overactive bladder: a

randomized controlled tria - Bohrium[EB].

[25]Miernik A, Gratzke C. Current Treatment for

Benign Prostatic Hyperplasia[J]. Deutsches Ärzteblatt

International, 2020, 117(49): 843.

[26]Rassweiler J, Teber D, Kuntz R,et al. Complications

of Transurethral Resection of the Prostate (TURP)—

Incidence, Management, and Prevention[J]. European

Urology, 2006, 50(5): 969-980.

[27]Cetti R J, Hicks J A, Venn S N, et al. RESULTS

FROM AN INTERNATIONAL MULTICENTRE

DOUBLE‐BLIND RANDOMIZED CONTROLLED

TRIAL ON THE PERIOPERATIVE EFFICACY

AND SAFETY OF BIPOLAR VS MONOPOLAR

T R A N S U R E T H R A L R E S E C T I O N O F T H E

PROSTATE[J]. BJU International, 2012, 109(11).

[28]Mamoulakis C, Trompetter M, De La Rosette J.

Bipolar transurethral resection of the prostate: the ‘golden

standard’ reclaims its leading position:[J]. Current Opinion in

Urology, 2009, 19(1): 26-32.

[29]Lerner L, Parsons J, Dahm P, et al. Surgical

Management of Lower Urinary Tract Symptoms Attributed

to Benign Prostatic Hyperplasia: AUA Guideline Amendment

2020.[J]. Journal of Urology, 2020.

[30]夏中友,伍季,李云祥,等.内镜下不同术式

的前列腺剜除术疗效对比[J].西部医学,2022,34(2):

225-228+234.

[31]Xue B, Zang Y, Zhang Y, et al. GreenLight HPS

120-W laser vaporization versus transurethral resection of

the prostate for treatment of benign prostatic hyperplasia: A

prospective randomized trial[J]. Journal of X-Ray Science

and Technology, 2013, 21(1): 125-132.

[32]Kuntzman R S, Malek R S, Barrett D M. HighPower Potassium Titanyl Phosphate Laser Vaporization

Prostatectomy[J]. Mayo Clinic Proceedings, 1998, 73(8):

798-801.

[33]Lan Y. Thulium (Tm:YAG) laser vaporesection

of prostate and bipolar transurethral resection of prostate in

patients with benign prostate hyperplasia: a systematic review

and meta-analysis[J]. Lasers Med Sci, 2018.

[34]Porpiglia F, Fiori C, Bertolo R, et al. 3-yearfollow-up of temporary implantable nitinol device

implantation for the treatment of benign prostatic obstruction.

[J]. BJU International, 2018, 122(1): 106-112.

[35]Chen D C, Qu L, Webb H, et al. Aquablation in

men with benign prostate hyperplasia: A systematic review

and meta-analysis[J]. Current Urology, 2023, 17(1).

[36]Kaplan S A. Re: rezūm Water Vapor Thermal

Therapy for Lower Urinary Tract Symptoms Associated

with Benign Prostatic Hyperplasia: 4-Year Results from

Randomized Controlled Study[J]. Journal of Urology, 2019,

202(1): 5-5.

[37]De Assis A M, Moreira A M, Carnevale F C,et al.

Role of Ultrasound Elastography in Patient Selection for

Prostatic Artery Embolization[J]. Journal of Vascular and

Interventional Radiology, 2021, 32(10): 1410-1416.

[38]Cerri G, Carnevale F, Antunes A, et al. MRI

findings after prostatic artery embolization for treatment

of benign hyperplasia.[J]. AJR. American journal of

roentgenology, 2014.

[39]Napal Lecumberri S, Insausti Gorbea I, Sáez De

Ocariz García A, et al. Prostatic artery embolization versus

transurethral resection of the prostate in the treatment of

benign prostatic hyperplasia: protocol for a non-inferiority

clinical trial[J]. Research and Reports in Urology, 2018,

Volume 10: 17-22.

[40]Bhatia S, Sinha V K, Harward S, et al. Prostate

Artery Embolization in Patients with Prostate Volumes of 80

mL or More: A Single-Institution Retrospective Experience

of 93 Patients[J]. Journal of Vascular and Interventional

Radiology, 2018, 29(10): 1392-1398.

[41]Bhatia S, Sinha V K, Kava B R, et al. Efficacy of

Prostatic Artery Embolization for Catheter-Dependent

Patients with Large Prostate Sizes and High Comorbidity

Scores[J]. Journal of Vascular and Interventional Radiology,

2018, 29(1): 78-84.e1.

[42]Wu X, Zhou A, Heller M, et al. Prostatic Artery

Embolization Versus Transurethral Resection of the Prostate

for Benign Prostatic Hyperplasia: A Cost-Effectiveness

Analysis[J]. Journal of Vascular and Interventional Radiology,

2022, 33(12): 1605-1615.

[43]Hashem E, Elsobky S, Khalifa M. Prostate Artery

Embolization for Benign Prostate Hyperplasia Review:

Patient Selection, Outcomes, and Technique[J]. Seminars in

Ultrasound, CT and MRI, 2020, 41(4): 357-365.

[44]Gelman J, Furr J. From open simple to roboticassisted

simple prostatectomy (RASP) for large benign prostate

hyperplasia: the time has come[J]. Journal of Endourology,

2020, 34(Suppl 1): S-2-S-6.


Refbacks

  • 当前没有refback。