非小细胞肺癌新辅助放疗联合免疫治疗——研究进展分析

鲁 姚1, 曾 义纯1, 耿 晓如1, 汪 步海1, 张 填填2
1、扬州大学附属苏北人民医院;扬州大学
2、扬州大学附属苏北人民医院;徐州医科大学

摘要


目前随着新辅助治疗的不断成熟,免疫检查点抑制剂在非小细胞肺癌中的应用取得了良好的效果。与单纯
新辅助放疗和单纯免疫治疗相比,新辅助放疗与免疫治疗的联合使用在非小细胞肺癌中显示出更好的临床结局和病
理完全缓解率。然而,目前暂无具体的治疗方案形成治疗标准。本文总结了新辅助放疗联合免疫治疗在非小细胞肺
癌中应用的一些临床研究,来对放疗的具体剂量与分割、放疗与免疫治疗的时序以及新辅助治疗完成后的手术间隔
等问题展开讨论。对放疗联合免疫治疗的具体作用机制及治疗的疗效生物标志物进行了总结。希望通过对新辅助放
疗联合免疫治疗非小细胞肺癌的具体过程、机制、疗效检测的进一步认识来为临床治疗方案的选择和未来临床研究
设计提供参考。

关键词


新辅助治疗;免疫治疗;放射治疗;非小细胞肺癌;生物标志物

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