髓系分化标志基因MYADM相关功能的研究进展
摘要
造血相关标记基因，编码的蛋白质属于MAL蛋白家族，在髓系细胞中高表达。其蛋白序列中的MARVEL结构域具
有重要生理和病理作用，参与膜泡运输、紧密连接等过程，与多种疾病相关。在髓系分化中，MYADM在单核细胞
等特定细胞中表达且诱导分化时上调表达，是髓系细胞分化发育的标记基因，在白血病发病机制等方面意义重大。
同时，MYADM参与膜蛋白分选转运、调节Rac1等分子信号通路，还与多种炎症发生发展，且在多种癌症中表达异
常并影响肿瘤细胞行为，是多种癌症的潜在诊断和治疗靶点。
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