蒽环类化疗药对乳腺癌患者体重的影响
摘要
癌治疗中的广泛应用。蒽环类药物作为基础化疗药物，具有显著的疗效，但其在治疗过程中常伴随体重变化问题。
研究显示，乳腺癌患者在接受蒽环类化疗后，通常会经历体重增加或减少的变化，这种变化与预后及复发率相关，
尤其是在欧洲人口中的非转移性乳腺癌患者中，这种变化与较差的预后相关联。
本综述深入探讨了蒽环类药物影响体重变化的潜在机制，通过比较不同研究的观点，本文进一步分析了乳腺癌
患者体重变化与病情预后的关系，以及蒽环类药物剂量调整对体重管理的影响。权衡各种策略在乳腺癌治疗中的应
用优势及其效果，从而为个性化治疗方案的制定提供科学依据。并展望未来蒽环类药物在乳腺癌治疗中的发展趋势
和应用前景。优化患者管理和提高治疗效果仍需大量深入研究和更大规模的临床试验支持。
关键词
全文:
PDF参考
[1]Siegel, R. L.; Miller, K. D.; Wagle, N. S.; Jemal, A.
Cancer Statistics, 2023. CA Cancer J Clin 2023, 73 (1), 17-
48. https://doi.org/10.3322/caac.21763.
[2]刘新义，奚凯雯，陈允允，甘露，吴怡颖，方
琼.乳腺癌病人辅助治疗期间体重变化研究进展.护理研
究2019，33（13），2267-2271.
[3]Thivat, E.; Thérondel, S.; Lapirot, O.; Abrial, C.;
Gimbergues, P.; Gadéa, E.; Planchat, E.; Kwiatkowski, F.;
Mouret-Reynier, M. A.; Chollet, P.; Durando, X. Weight
Change during Chemotherapy Changes the Prognosis in Non
Metastatic Breast Cancer for the Worse. BMC Cancer 2010,
10, 648. https://doi.org/10.1186/1471-2407-10-648.
[4]Pedersen, B.; Delmar, C.; Bendtsen, M. D.; Bosaeus,
I.; Carus, A.; Falkmer, U.; Groenkjaer, M. Changes in
Weight and Body Composition Among Women With Breast
Cancer During and After Adjuvant Treatment: A Prospective
Follow-up Study. Cancer Nurs 2017, 40 (5), 369-376.
https://doi.org/10.1097/NCC.0000000000000426.
[5]Winkels, R. M. Changes in Body Weight during
Various Types of Chemotherapy in Breast Cancer Patients. 2014.
[6]Martins-Teixeira, M. B.; Carvalho, I. Antitumour
Anthracyclines: Progress and Perspectives. ChemMedChem
2020, 15 (11), 933-948. https://doi.org/10.1002/
cmdc.202000131.
[7]Anthracyclines in the treatment of early breast cancer
friend or foe? - PubMed. https://pubmed.ncbi.nlm.nih.
gov/35839583/ (accessed 2025-01-06).
[8]van den Berg, M. M. G. A.; Winkels, R. M.; de
Kruif, J. T. C. M.; van Laarhoven, H. W. M.; Visser, M.;
de Vries, J. H. M.; de Vries, Y. C.; Kampman, E. Weight
Change during Chemotherapy in Breast Cancer Patients: A
Meta-Analysis. BMC Cancer 2017, 17 (1), 259. https://doi.
org/10.1186/s12885-017-3242-4.
[9]Fukui, J.; White, K.; Frankland, T. B.; Oshiro, C.;
Wilkens, L. Weight Changes According to Treatment in a
Diverse Cohort of Breast Cancer Patients. BMC Cancer 2021,
21 (1), 1005. https://doi.org/10.1186/s12885-021-08740-5.
[10]Lucarelli, A. P.; Martins, M. M.; Guedes, J. M.
Correlation between the Body Mass Index of Patients with
Breast Cancer before and after Chemotherapy. Eur J Gynaecol
Oncol 2017, 38 (2), 187-190.
[11]Andrieu-Abadie, N. [Cardiotoxicity ofanthracyclines: mechanisms and pharmacologic targets for
prevention]. Therapie 2004, 59 (1), 121-126. https://doi.
org/10.2515/therapie:2004023.
[12]Varghese, S. S.; Eekhoudt, C. R.; Jassal, D. S.
Mechanisms of Anthracycline-Mediated Cardiotoxicity
and Preventative Strategies in Women with Breast Cancer.
Mol Cell Biochem 2021, 476 (8), 3099-3109. https://doi.
org/10.1007/s11010-021-04152-y.
[13]Teixeira, J. F. C.; Maia-Lemos, P. D. S.; Cypriano,
M. D. S.; Pisani, L. P. The Influence of Antineoplastic
Treatment on the Weight of Survivors of Childhood
Cancer. J Pediatr (Rio J) 2016, 92 (6), 559-566. https://doi.
org/10.1016/j.jped.2016.04.003.
[14]Reis-Mendes, A. F.; Sousa, E.; de Lourdes Bastos,
M.; Costa, V. M. The Role of the Metabolism of Anticancer
Drugs in Their Induced-Cardiotoxicity. Curr Drug Metab
2015, 17 (1), 75-90. https://doi.org/10.2174/138920021666
6151103114926.
[15]de Kruif, A. Jt.; Westerman, M. J.; Winkels, R. M.;
Koster, M. S.; van der Staaij, I. M.; van den Berg, M. M. G. A.;
de Vries, J. H. M.; de Boer, M. R.; Kampman, E.; Visser, M.
Exploring Changes in Dietary Intake, Physical Activity and
Body Weight during Chemotherapy in Women with Breast
Cancer: A Mixed-Methods Study. J Hum Nutr Diet 2021,
34 (3), 550-561. https://doi.org/10.1111/jhn.12843.
[16]Chen, X.; Lu, W.; Zheng, W.; Gu, K.; Chen,
Z.; Zheng, Y.; Shu, X. O. Obesity and Weight Change in
Relation to Breast Cancer Survival. Breast Cancer Res Treat
2010, 122 (3), 823-833. https://doi.org/10.1007/s10549-
009-0708-3.
[17]Rodríguez San Felipe, M. J.; Aguilar Martínez,
A.; Manuel-y-Keenoy, B. [Influence of body weight on the
prognosis of breast cancer survivors; nutritional approach after
diagnosis]. Nutr Hosp 2013, 28 (6), 1829-1841.
[18]Caan, B. J.; Kwan, M. L.; Shu, X. O.; Pierce, J. P.;
Patterson, R. E.; Nechuta, S. J.; Poole, E. M.; Kroenke, C. H.;
Weltzien, E. K.; Flatt, S. W.; Quesenberry, C. P.; Holmes,
M. D.; Chen, W. Y. Weight Change and Survival after Breast
Cancer in the after Breast Cancer Pooling Project. Cancer
Epidemiol Biomarkers Prev 2012, 21 (8), 1260-1271. https://
doi.org/10.1158/1055-9965.EPI-12-0306.
[19]Cihan, Y. B. Relationship of Body Mass Index with
Prognosis in Breast Cancer Patients Treated with Adjuvant
Radiotherapy and Chemotherapy. Asian Pac J Cancer
Prev 2014, 15 (10), 4233-4238. https://doi.org/10.7314/
apjcp.2014.15.10.4233.
[20]Gadéa, É.; Thivat, É.; Wang-Lopez, Q.; Viala,
M.; Paulon, R.; Planchat, É.; Chadeyras, J.-B.; Merlin, C.;
Coudert, B.; Bignon, Y.-J.; Morio, B.; Durando, X. [Poor
prognostic value of weight change during chemotherapy in
non-metastatic breast cancer patients: causes, mechanisms
involved and preventive strategies]. Bull Cancer 2013, 100 (9),
865-870. https://doi.org/10.1684/bdc.2013.1802.
[21]Zhang, Y.-X.; Liang, Z.-Z.; Li, Y.-Q.; Lin, Y.;
Liu, Q.; Xie, X.-M.; Tang, L.-Y.; Ren, Z.-F. Association
between Weight Change and Breast Cancer Prognosis. Breast
Cancer Res Treat 2022, 193 (3), 677-684. https://doi.
org/10.1007/s10549-022-06592-6.
[22]Body weight changes after adjuvant chemotherapy of
patients with breast cancer: results of a Mexican cohort study
- PubMed. https://pubmed.ncbi.nlm.nih.gov/27476826/
(accessed 2025-01-13).
Refbacks
- 当前没有refback。
