m6A甲基化修饰在呼吸系统疾病中的作用研究进展

陈 佳美, 李建 民*
湖南省人民医院（湖南师范大学附属第一医院）

摘要


N6-腺苷酸甲基化（m6A）是mRNA中最丰富的内部修饰，与许多生物过程和疾病有关，对机体的生长发
育、代谢及炎症反应等生理过程产生影响。同时，m6A甲基化的失调与肺癌患者的耐药性和不良预后有关，m6A调
节剂可以是耐药性的可行治疗和靶向治疗的新药靶标。因此，本综述主要对m6A甲基化修饰与呼吸系统相关疾病进
行回顾和总结。

关键词


呼吸系统疾病；N6-腺苷酸甲基化；RNA修饰

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参考


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