微小RNA-148在肿瘤中研究进展

蹇 卓雅
青海大学研究生院

摘要


本综述聚焦microRNA-148（miR-148）在肿瘤发生、发展进程中的多层面角色。整合近年研究成果，阐
述其在肿瘤细胞增殖、侵袭转移、凋亡调控及肿瘤微环境塑造等方面机制，剖析作为生物标志物与治疗靶点的潜能，
为肿瘤诊疗新思路提供参考。

关键词


miR-148；肿瘤生物学；生物标志物；靶向治疗

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参考


[1]张鹏，韩从辉，刘大闯.微小RNA与前列腺癌关

系的研究进展[J].中国医药，2025，20（02）：313-315.

[2]Y Li, X Deng, X Zeng, et al. The Role of Mir-148a

in Cancer [J]. Journal of Cancer, 2016, 7(10): 1233-41.

[3]H Fu, Y Tie, C Xu, et al. Identification of human

fetal liver miRNAs by a novel method [J]. FEBS letters, 2005,

579(17): 3849-54.

[4]张 一 帆， 周 梁.miRNA-148/152家 族 成 员 在 恶

性肿瘤中的生物学功能研究进展[J].复旦学报医学版，

2022，49（3）：447-453.

[5]Li, Z., Xu, Q., Zhong, J. et al. Structural insights

into RNA cleavage by PIWI Argonaute [J]. Nature，2025,

10.1038.

[6]CUK K, ZUCKNICK M, HEIL J, et al. Circulating

microRNAs in plasma as early detection markers for breast

cancer[J]. Int J Cancer, 2013, 132(7): 1602-1612.

[7]XU Q, JIANG Y, YIN Y, et al. A regulatory

circuit of miR-148a/152 and DNMT1 in modulating cell

transformation and tumor angiogenesis through IGF-IR and

IRS1[J]. J Mol Cell Biol, 2013, 5(1): 3-13.

[8]赵越，贾户亮，周海军，等.肝癌转移相关的微

小RNAs在不同转移潜能肝癌细胞系的定量研究[J].中华

肝脏病杂志，2009，17（7）：526-530.

[9]SONG Y, XU Y, WANG Z, et al. MicroRNA-

148b suppresses cell growth by targeting cholecystokinin-2

receptor in colorectal cancer[J]. Int J Cancer, 2012, 131(5):

1042-1051.

[10]FRIEDRICH M, PRACHT K, MASHREGHI M

F, et al. The role of the miR-148/-152 family in physiology

and disease [J]. European journal of immunology, 2017,

47(12): 2026-38.

[11]CHEN B, GU Y, SHEN H, et al. Borealin Promotes

Tumor Growth and Metastasis by Activating the Wnt/

β-Catenin Signaling Pathway in Hepatocellular Carcinoma [J].

Journal of hepatocellular carcinoma, 2022, 9: 171-88.

[12]XI J, SHI L, ZHOU D, et al. Effects of LINC00261

targeting miR-148a/WNT10b axis on the proliferation and

apoptosis of colorectal cancer cells [J]. Heliyon, 2023, 9(11):

e22094.

[13]WANG X, LIANG Z, XU X, et al. miR-148a-

3p represses proliferation and EMT by establishing regulatory

circuits between ERBB3/AKT2/c-myc and DNMT1 in

bladder cancer [J]. Cell death & disease, 2016, 7(12): e2503.

[14]ZHANG H, LIANG F, WANG F, et al. miR-

148-3p inhibits gastric cancer cell malignant phenotypes and

chemotherapy resistance by targeting Bcl2 [J]. Bioengineered,

2024, 15(1): 2005742.

[15]FENG F, LIU H, CHEN A, et al. miR-148-3p

and miR-152-3p synergistically regulate prostate cancer

progression via repressing KLF4 [J]. Journal of cellular

biochemistry, 2019, 120(10): 17228-39.

[16]李文玺，张华.肿瘤微环境在喉癌转移中的作用

及机制[J].河北医药，2025，47（01）：123-127.

[17]KARPATHIOU G, DUMOLLARD J M, PEOC'H

M. Laryngeal Tumor Microenvironment [J]. Advances in

experimental medicine and biology, 2020, 1296: 79-101.

[18]HUANG F, ZHAO J L, WANG L, et al. miR-

148a-3p Mediates Notch Signaling to Promote the

Differentiation and M1 Activation of Macrophages [J].

Frontiers in immunology, 2017, 8: 1327.

[19]HAFLIDADóTTIR B S, BERGSTEINSDóTTIR

K, PRAETORIUS C, et al. miR-148 regulates Mitf in

melanoma cells [J]. PloS one, 2010, 5(7): e11574.

[20]张天瑾，陈兆峰，王玉平，等.肿瘤标志物在胃

癌预后判断应用中的研究进展[J].胃肠病学和肝病学杂

志，2017，26（12）：1321-1326.

[21]WANG F, YING H, HE B, et al. Circulating miR-

148/152 family as potential biomarkers in hepatocellular

carcinoma [J]. Tumour biology: the journal of the

International Society for Oncodevelopmental Biology and

Medicine, 2016, 37(4): 4945-53.

[22]LI L, CHEN Y Y, LI S Q, et al. Expression of miR-

148/152 family as potential biomarkers in non-small-cell lung

cancer [J]. Medical science monitor: international medical journal

of experimental and clinical research, 2015, 21: 1155-61.

[23]DORRAKI N, GHALE-NOIE Z N, AHMADI

N S, et al. miRNA-148b and its role in various cancers [J].

Epigenomics, 2021, 13(24): 1939-60.

[24]LI B, XIE Z, LI B. miR-152 functions as a tumor

suppressor in colorectal cancer by targeting PIK3R3[J].

Tumour Biol, 2016, 37(8): 1-10.


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