局部脑氧饱和度监测技术在术后认知功能障碍 预测中的应用进展

张 子豪1, 王 云2
1、青海大学研究生院
2、青海省人民医院

摘要


POCD(Postoperative Cognitive Dysfunction)即术后认知功能障碍,是一种常见于手术和麻醉后的中枢神
经系统的并发症,它表现为患者的学习能力、方向感、记忆力、决策能力和专注度等方面相对于手术前的状态有
明显的降低[1]。目前研究普遍认为认知能力的下降是暂时性的、有自愈性,绝大部分被影响的患者最终都能恢复到
术前水平,然而一小部分可能遗留持续性的认知障碍,甚至是发展为痴呆[2]。早既往研究认为老年人群行心脏手术
后的术后认知障碍(POCD)发病率较高。但最近研究已经显示各年龄组患者在接受全麻非心脏手术后均可能发生
POCD[3]。POCD造成患者术后恢复差,延长住院时间,增加住院成本,需要长期康复支持。本文拟对局部脑氧饱和
度监测技术应用于预测患者术后认知功能障碍方面的最新应用进展进行综述。

关键词


术后认知功能障碍;脑氧饱和度

全文:

PDF


参考


[1]Rundshagen I. Postoperative cognitive dysfunction.

Dtsch Arztebl Int. 2014 Feb 21;111(8):119-25. doi: 10.3238/

arztebl.2014.0119IF: 7.7 Q1 . PMID: 24622758; PMCID:

PMC3959222.

[2]Krenk L , Rasmussen L S , Kehlet H .New insights

into the pathophysiology of postoperative cognitive

dysfunction[J].Acta Anaesthesiologica Scandinavica, 2010,

54(8).DOI:10.1111/j.1399-6576.2010.02268.x

[3]epousé,C A,Lautner,et al.Emergence delirium in

adults in the post-anaesthesia care unit.[J].British journal of

anaesthesia, 2006

[4]Biying L ,Dan H ,Yunlu G , et al.Recent advances

and perspectives of postoperative neurological disorders

in the elderly surgical patients.[J].CNS neuroscience &

therapeutics,2021,28(4):470-483.

[5]高璇,仓静.脑氧饱和度监测在预测术后认知功

能障碍的应用进展[J].临床麻醉学杂志,2015,31(08):

820-823.

[6]赵倩文,孙斌,朱杨子,等.老年病人术后认知

功能障碍诊断与干预策略的研究进展[J].实用老年医学,

2024,38(05):447-451.

[7]冉娇,李雪寒.术后认知障碍评估量表的研究进

展[J].重庆医学,2022,51(03):533-537.

[8]Tayar AA, Abouelela A, Mohiuddeen K. Can the

cerebral regional oxygen saturation be a perfusion parameter

in shock? [J]. J Crit Care, 2017, 38: 164-167

[9]Yu P , Wang H , Mu L ,et al.Effect of general

anesthesia on serum β-amyloid protein and regional

cerebral oxygen saturation of elderly patients after subtotal

gastrectomy[J].Experimental and therapeutic medicine, 2016.

DOI:10.3892/etm.2016.3814.

[10]Arnaud F ,Matthias J ,Jean-Luc F .Four-wavelength

near-infrared peripheral oximetry in cardiac surgery patients:

a comparison between EQUANOX and O3.[J].Journal of

clinical monitoring and computing,2018,32(2):253-259.

[11]李阳.近红外光谱技术测定国人脑氧饱和度基线

值及其影响因素的研究[D].中国人民解放军陆军军医大

学,2023.DOI:10.27001/d.cnki.gtjyu.2023.000282

[12]Zhili J ,Di W .Application of regional cerebral oxygen

saturation monitoring with near-infrared spectroscopy in

peri-anesthesia management of elderly hypertensive patients

undergoing shoulder arthroscopic surgery.[J].American journal

of translational research,2021,13(5):5568-5574.

[13]丁超,孙莉,张燕等.老年食管癌患者全身麻醉

术后认知功能障碍与术中脑氧饱和度变化的关系[J].中国

医刊,2012,47(04):42-44.

[14]许高璇,仓静.脑氧饱和度监测在预测术后认知

功能障碍的应用进展[J].临床麻醉学杂志,2015,31(08):

820-823.

[15]王雅婷,仓静,方芳.影响术后认知功能障碍

发生的非外科疾病因素研究进展[J].临床麻醉学杂志,

2017,33(01):95-98.[16]Julika S ,Joscha M ,Hauke P , et al.Preoperative

regional cerebral oxygen saturation is a predictor of

postoperative delirium in on-pump cardiac surgery patients:

a prospective observational trial.[J].Critical care (London,

England),2011,15(5):R218.

[17]Schoen J , Meyerrose J , Paarmann H ,et

al.Preoperative regional cerebral oxygen saturation is a predictor

of postoperative delirium in on-pump cardiac surgery patients:

a prospective observational trial[J].Critical care (London,

England), 2011, 15(5):R218.DOI:10.1186/cc10454.

[18]Papadopoulos G ,Karanikolas M ,Liarmakopoulou

A , et al.Baseline cerebral oximetry values in elderly patients

with hip fractures: A prospective observational study[J].

Injury,2011,42(11):1328-1332.

[19]B A F ,Dmitry T ,E E W , et al.Changes in tissue and

cerebral oxygenation following spinal anesthesia in infants: a

prospective study.[J].Journal of anesthesia,2018,32(2):288-292.

[20]Susano J M ,Dias M ,Seixas S F , et al.Association

Among Preoperative Cognitive Performance, Regional Cerebral

Oxygen Saturation, and Postoperative Delirium in Older

Portuguese Patients.[J].Anesthesia and analgesia, 2020, 132(3):

[21]苏秀珠,张燕,王丽萍.脑氧饱和度监测目标

导向技术在老年患者围术期脑保护中的作用[J].中国医

药 导 报,2021,18(07):95-98+112.DOI:10.20047/

j.issn1673-7210.2021.07.024

[22]仇灵琴,葛莉,周海娇.术中监测局部脑氧饱

和度在老年直肠癌根治术患者POD中的预测价值[J].中

国 医 药 科 学,2024,14(06):84-87.DOI:10.20116/

j.issn2095-0616.2024.06.19

[23]L T ,R K ,R T , et al.Reduced cerebral oxygen

saturation during thoracic surgery predicts early postoperative

cognitive dysfunction.[J].British journal of anaesthesia, 2012,

108(4): 623-9.

[24]Andres Z ,Ryan H ,C M G , et al.Intraoperative

cerebral oximetry-based management for optimizing

perioperative outcomes: a meta-analysis of randomized

controlled trials.[J].Canadian journal of anaesthesia = Journal

canadien d'anesthesie, 2018,65(5):529-542.

[25]Zheng F, Sheinberg R, Yee MS, Ono M, Zheng Y,

Hogue CW. Cerebral near-infrared spectroscopy monitoring

and neurologic outcomes in adult cardiac surgery patients: a

systematic review. Anesth Analg. 2013 Mar;116(3):663-76.

[26]杨帆,何施谦,郭尹浩,等.脑氧饱和度在术

后神经认知障碍预测中的应用进展[J].麻醉安全与质控,

2024,6(02):117-120.

[27]刘畅,薛云星,陈杨,等.脑氧饱和度监测与

急性A型主动脉夹层患者术后脑卒中相关性的研究[J].

中 华 心 血 管 病 杂 志,2022,50(8):761-766. DOI:

10.3760/cma.j.cn112148-20220403-00237.

[28]Evered LA, Silbert BS. Postoperative Cognitive

Dysfunction and Noncardiac Surgery. Anesth Analg. 2018

Aug;127(2):496-505. doi: 10.1213/ANE.0000000000003514.

PMID: 29889707.

[29][1]Juan L T ,Su Y ,Hui C Z , et al.The Effect

of Intraoperative Cerebral Oximetry Monitoring on

Postoperative Cognitive Dysfunction and ICU Stay in Adult

Patients Undergoing Cardiac Surgery: An Updated Systematic

Review and Meta-Analysis [J].Frontiers in Cardiovascular

Medicine,2022,8814313-814313.

[30]M J M ,J S A ,J R N , et al.Monitoring brain oxygen

saturation during coronary bypass surgery: a randomized,

prospective study.[J].Anesthesia and analgesia, 2007, 104(1):

51-8.

[31]缪长虹.近红外光局部脑氧与组织氧饱和度监测

在心胸血管手术麻醉中应用的专家共识(2023版)[J].临

床麻醉学杂志,2023,39(10):1103-1110.

[32]Hemmerling TM, Bluteau MC, Kazan R, Bracco

D. Significant decrease of cerebral oxygen saturation during

single-lung ventilation measured using absolute oximetry. Br

J Anaesth. 2008 Dec;101(6):870-5. doi: 10.1093/bja/aen275.

Epub 2008 Oct 3. PMID: 18835887.

[33]Kazan R, Bracco D, Hemmerling TM. Reduced

cerebral oxygen saturation measured by absolute cerebral

oximetry during thoracic surgery correlates with postoperative

complications. Br J Anaesth. 2009 Dec;103(6):811-6. doi:

10.1093/bja/aep309. PMID: 19918024.

[34]Yu J W ,Ming L ,Pei W , et al.Goal-directed therapy

based on rScO2 monitoring in elderly patients with one-lung

ventilation: a randomized trial on perioperative inflammation

and postoperative delirium[J].Trials,2022,23(1):687-687.

[35]李茜,昂扬,施敏,等.脑氧饱和度监测对骨

科高龄患者术后谵妄的预测价值[J].医学研究生学报,

2022,35(10):1059-1063.DOI:10.16571/j.cnki.1008-

8199.2022.10.010.


Refbacks

  • 当前没有refback。