植物外泌体样纳米囊泡在创面修复的研究进展

郝 淑艳1, 王献 珍*2
1、青海大学临床医学院
2、青海大学附属医院烧伤科

摘要


创面修复在医疗领域面临着日益凸显的困难与挑战，创面恢复关乎患者的生活质量与健康恢复。近年来有关植物来源外泌体样纳米囊泡的研究，逐渐在创面修复领域展现出独特优势。本综述简要概括了植物外泌体样纳米囊泡（plant exocrine-like nano-vesicles，PELNs）促进细胞增殖与迁移、调节炎症反应、血管生成作用、在创面修复中的应用研究现状等方面的研究进展，揭示PELNs对创面修复的影响旨在为其后续深入研究提供理论依据与参考。

关键词


植物外泌体样纳米囊泡；组成成分；机制；修复；创面

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参考


[1]Fulbrook P, Lawrence P, Miles S. Australian Nurses’ Knowledge of Pressure Injury Prevention and Management: A Cross-sectional Survey[J]. Journal of Wound, Ostomy & Continence Nursing, 2019, 46(2): 106-112.

[2]Reinke J M, Sorg H. Wound repair and regeneration[J]. European Surgical Research, 2012, 49(1): 35-43.

[3]Mustoe T A, O’Shaughnessy K, Kloeters O. Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis[J]. Plastic and Reconstructive Surgery, 2006, 117(SUPPLEMENT): 35S-41S.

[4]Zhou Y, Tian T, Zhu Y, et al. Exosomes Transfer Among Different Species Cells and Mediating miRNAs Delivery[J]. Journal of Cellular Biochemistry, 2017, 118(12): 4267-4274.

[5]Zhang Y, Bi J, Huang J, et al. Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications[J]. International Journal of Nanomedicine, 2020, Volume 15: 6917-6934.

[6]Kim J, Li S, Zhang S, et al. Plant-derived exosome-like nanoparticles and their therapeutic activities[J]. Asian Journal of Pharmaceutical Sciences, 2022, 17(1): 53-69.

[7]Şahin F, Koçak P, Güneş M Y, et al. In Vitro Wound Healing Activity of Wheat-Derived Nanovesicles[J]. Applied Biochemistry and Biotechnology, 2019, 188(2): 381-394.

[8]Ridiandries A, Tan J T M, Bursill C A. The Role of Chemokines in Wound Healing[J]. International Journal of Molecular Sciences, 2018, 19(10): 3217.

[9]Tonnesen M G, Feng X, Clark R A F. Angiogenesis in wound healing[J]. Journal of Investigative Dermatology Symposium Proceedings, 2000, 5(1): 40-46.

[10]Cui Y, Gao J, He Y, et al. Plant extracellular vesicles[J]. Protoplasma, 2020, 257(1): 3-12.

[11]Cong M, Tan S, Li S, et al. Technology insight: Plant-derived vesicles-How far from the clinical biotherapeutics and therapeutic drug carriers?[J]. Advanced Drug Delivery Reviews, 2022, 182: 114108.

[12]张雪萍，鲁雨晴，张月倩，等.植物细胞外囊泡及其分析技术的进展[J].生物技术通报，2023，39（5）：32-43.

[13]Hatsugai N, Iwasaki S, Tamura K, et al. A novel membrane fusion-mediated plant immunity against bacterial pathogens[J]. Genes & Development, 2009, 23(21): 2496-2506.

[14]Subha D, AnuKiruthika R, Sreeraj H, 等. Plant exosomes: nano conveyors of pathogen resistance[J]. Discover Nano, 2023, 18(1): 146.

[15]Rupert D L M, Claudio V, Lässer C, et al. Methods for the physical characterization and quantification of extracellular vesicles in biological samples[J]. Biochimica et Biophysica Acta (BBA) - General Subjects, 2017, 1861(1): 3164-3179.

[16]夏贤霆，王卫明，黄昊强，等.植物来源外泌体样纳米囊泡在骨质疏松及骨关节炎中的作用[J].华西医学，2025，40（1）：147-152.

[17]Wang Y, Wei Y, Liao H, et al. Plant Exosome-like Nanoparticles as Biological Shuttles for Transdermal Drug Delivery[J]. Bioengineering, 2023, 10(1): 104.

[18]Baldini N, Torreggiani E, Roncuzzi L, et al. Exosome-like Nanovesicles Isolated from Citrus limon L. Exert Antioxidative Effect[J]. Current Pharmaceutical Biotechnology, 2018, 19(11): 877-885.

[19]Wang B, Zhuang X, Deng Z B, et al. Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit[J]. Molecular Therapy, 2014, 22(3): 522-534.

[20]Savcı Y, Kırbaş O K, Bozkurt B T, et al. Grapefruit-derived extracellular vesicles as a promising cell-free therapeutic tool for wound healing[J]. Food & Function, 2021, 12(11): 5144-5156.

[21]Kim M K, Choi Y C, Cho S H, et al. The Antioxidant Effect of Small Extracellular Vesicles Derived from Aloe vera Peels for Wound Healing[J]. Tissue Engineering and Regenerative Medicine, 2021, 18(4): 561-571.

[22]Natania F, Iriawati I, Ayuningtyas F D, et al. Potential of Plant-derived Exosome-like Nanoparticles from Physalis peruviana Fruit for Human Dermal Fibroblast Regeneration and Remodeling[J]. Pharmaceutical Nanotechnology, 2025, 13(2): 358-371.

[23]Daniello V, De Leo V, Lasalvia M, et al. Solanum lycopersicum (Tomato)-Derived Nanovesicles Accelerate Wound Healing by Eliciting the Migration of Keratinocytes and Fibroblasts[J]. International Journal of Molecular Sciences, 2024, 25(5): 2452.

[24]陈正琳.金银花外泌体样纳米囊泡促进糖尿病慢性创面愈合的研究[D].杭州：浙江中医药大学，[2025].

[25]Zhang S, Xia J, Zhu Y, et al. Establishing Salvia miltiorrhiza-Derived Exosome-like Nanoparticles and Elucidating Their Role in Angiogenesis[J]. Molecules, 2024, 29(7): 1599.

[26]Mahdipour E. Beta vulgaris juice contains biologically active exosome-like nanoparticles[J]. Tissue and Cell, 2022, 76: 101800.

[27]Raimondo S, Urzì O, Meraviglia S, et al. Anti-inflammatory properties of lemon-derived extracellular vesicles are achieved through the inhibition of ERK/NF-κB signalling pathways[J]. Journal of Cellular and Molecular Medicine, 2022, 26(15): 4195-4209.

[28]Ramírez O, Pomareda F, Olivares B, et al. Aloe vera peel-derived nanovesicles display anti-inflammatory properties and prevent myofibroblast differentiation[J]. Phytomedicine, 2024, 122: 155108.

[29]Tu J, Jiang F, Fang J, et al. Anticipation and Verification of Dendrobium-Derived Nanovesicles for Skin Wound Healing Targets, Predicated Upon Immune Infiltration and Senescence[J]. International Journal of Nanomedicine, 2024, Volume 19: 1629-1644.

[30]Wu J, Ma X, Lu Y, et al. Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization[J]. Molecules, 2022, 27(23): 8184.

[31]Wu B, Pan W, Luo S, et al. Turmeric-Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing[J]. Advanced Science, 2024, 11(18): 2307630.

[32]Ou X, Wang H, Tie H, et al. Novel plant-derived exosome-like nanovesicles from Catharanthus roseus: preparation, characterization, and immunostimulatory effect via TNF-α/NF-κB/PU.1 axis[J]. Journal of Nanobiotechnology, 2023, 21(1): 160.

[33]Tan S, Liu Z, Cong M, et al. Dandelion-derived vesicles-laden hydrogel dressings capable of neutralizing Staphylococcus aureus exotoxins for the care of invasive wounds[J]. Journal of Controlled Release, 2024, 368: 355-371.


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