TyG指数联合SII对老年人发生冠心病及冠脉狭窄程度的预测价值

廖 旭鹏1, 方 敏*2
1、汕头大学医学院 全科医学科
2、惠州市中心人民医院

摘要


目的:探讨TyG指数(甘油三酯-葡萄糖乘积指数)和SII(系统性免疫炎症指数)对老年人冠心病及冠脉狭窄程度的预测价值。方法:收集2023年8月至2024年1月在惠州市中心人民医院心血管内科住院治疗的263例老年患者的临床资料,其中冠心病组139例,非冠心病组124例,分析两组患者的一般资料及血液生化指标的差异。采用Logistic回归分析影响老年患者发生冠心病及冠脉高危病变的危险因素,通过受试者操作特征曲线(ROC)分析老年患者发生冠心病及冠脉病变程度的诊断价值。结果:老年冠心病组男性比例、高血压病史、舒张压、BMI、SII、TyG指数、白细胞、中性粒细胞、血小板计数、甘油三酯(TG)、血尿酸(UA)、血肌酐(Scr)、糖化血红蛋白(HbA1c)、空腹血糖(FPG)较老年非冠心病组高,高密度脂蛋白(HDL-C)较低,差异具有统计学意义(P<0.05);Logistic回归分析显示,调整混杂因素后,TyG指数和SII是老年患者发生冠心病及冠脉高危病变的独立危险因素,差异具有统计学意义(P<0.05)。ROC曲线分析显示,TyG指数、SII预测老年患者发生冠心病的AUC分别为0.696、0.699(P<0.05),两指标联合预测的AUC为0.757(P<0.05);TyG指数、SII预测老年患者发生冠脉高危病变(Gensini评分>10分)的AUC分别为0.681、0.679(P<0.05),两指标联合预测的AUC为0.737(P<0.05)。结论:1.SII、TyG指数是老年患者发生冠心病及冠脉高危病变的独立危险因素;2.SII、TyG指数对老年患者发生冠心病及冠脉高危病变具有一定诊断价值,两者联合预测,诊断效能更佳。

关键词


甘油三酯-葡萄糖乘积指数;系统性免疫炎症指数;冠心病;老年人;预测价值

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参考


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