Hedgehog信号通路与口腔鳞状细胞癌

何 露萱
浙江中医药大学

摘要


口腔鳞状细胞癌（OCSCC）作为口腔高侵袭性恶性肿瘤，其发生发展及转移机制尚未完全阐明，现有研究证实该疾病进程与信号转导网络异常激活密切相关。Hedgehog（Hh）信号通路作为在哺乳动物胚胎发育、组织形成及细胞迁移等过程中发挥关键调控作用的分子通路，其活性受多层级精密调控。近年研究提示Hh通路在舌鳞状细胞癌病理进程中具有关键调控价值。本综述聚焦Hh通路分子机制及其在口腔恶性肿瘤中的研究进展，旨在为疾病机制解析与诊疗策略优化提供理论支持。

关键词


Hedgehog信号通路；口腔鳞状细胞癌

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参考


[1]郑家伟，李金忠，涂文勇，张陈平，郭传瑸，李龙江，孙沫逸，韩正学，廖贵清，潘潮斌，张文峰，季彤.口腔颌面部恶性肿瘤治疗指南[J].中国口腔颌面外科杂志，2010，8（02）：98-106.

[2]Nüsslein-Volhard, C., & Wieschaus, E. (1980). Mutations affecting segment number and polarity in Drosophila. Nature, 287(5785), 795-801. https://doi.org/10.1038/287795a0

[3]Nguyen, N.M.; Cho, J. Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance. Int. J. Mol. Sci. 2022, 23, 1733. https://doi.org/10.3390/ijms23031733

[4]Doheny, D., Manore, S. G., Wong, G. L., & Lo, H. W. (2020). Hedgehog Signaling and Truncated GLI1 in Cancer. Cells, 9(9), 2114. https://doi.org/10.3390/cells9092114

[5]Nishimaki, H., Kasai, K., Kozaki, K.i, Takeo, T., Ikeda, H., Saga, S., Nitta, M., & Itoh, G. (2004). A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line. Biochemical and biophysical research communications, 314(2), 313-320. https://doi.org/10.1016/j.bbrc.2003.12.097

[6]Wang, Y. F., Chang, C. J., Lin, C. P., Chang, S. Y., Chu, P. Y., Tai, S. K., Li, W. Y., Chao, K. S., & Chen, Y. J. (2012). Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma. Head & neck, 34(11), 1556-1561. https://doi.org/10.1002/hed.21958


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