炎症-脂质代谢轴对认知功能影响的研究进展

张 沛祯1, 刘军 莉*2
1、青海大学
2、青海大学附属医院

摘要


认知功能衰退是老龄化过程中常见的神经退行性过程，严重者可发展为血管性认知损害或阿尔茨海默病。近年来，研究表明，慢性低度炎症与脂质代谢异常相互作用，形成“炎症-脂质代谢轴”，并通过诱导神经炎症、损害突触可塑性及破坏血管功能等机制，加速神经退行性变。本综述系统梳理该轴在认知功能衰退中的作用机制，并探讨抗炎治疗、脂质代谢调控及综合生活方式干预等潜在策略。未来研究应进一步明确该轴在不同类型认知障碍中的特异性作用，并优化精准干预策略，以有效延缓认知功能衰退，提高老年人群的认知健康水平。

关键词


慢性低度炎症；脂质代谢异常；残余胆固醇；血管性认知损害；阿尔茨海默病

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参考


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