急性胰腺炎早期严重程度预测指标的研究进展

候 永华, 王 聪*
青海大学附属医院肝胆胰外科;青海省包虫病研究重点实验室

摘要


急性胰腺炎（AP）是一种以腹痛为主要临床表现的外科常见疾病，而胆道疾病、高脂血症和酗酒是AP的三大主要病因。临床上常用的急性胰腺炎预测评分系统包括Ranson评分和BISAP评分等，但这些评分系统因变量较多、数据获取复杂且观察周期长，难以及时、全面地反映胰腺炎的严重程度。相比之下，实验室指标因其简便易行、易于获取且可以动态监测等优势，在AP的评估中发挥了不可忽视的作用。近年来，越来越多的研究开始关注一些新型的实验室指标，这些指标能够快速获取并且能够初步判断病情的严重程度，为临床决策提供了重要参考。为了引起临床医师对这些指标的重视，本文将对一些新型实验室指标在评估急性胰腺炎严重程度方面的研究进展进行综述，旨在为临床医生在AP的评估及治疗中提供科学依据与指导。

关键词


急性胰腺炎；严重程度；预测；实验室指标

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参考


[1]A P B, L T B, Christos D, et al.Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus.[J].Gut, 2013, 62(1): 102-11.

[2]Matthieu J, Nouria B, Thomas R, et al.Thoracic Epidural Analgesia and Mortality in Acute Pancreatitis: A Multicenter Propensity Analysis.[J].Critical care medicine, 2018, 46(3): e198-e205.

[3]E T P, T E P, K A S. Advances in prognostic factors in acute pancreatitis: a mini-review.[J].Hepatobiliary & pancreatic diseases international: HBPD INT, 2010, 9(5): 482-6.

[4]邹慧莹，马捷，肖京京.肺部超声B线积分及新型炎症标志物对糖尿病肾病维持性血液透析患者心血管事件风险模型的构建及验证[J].中国医药导报，2024，21（18）：5-9+20.DOI：10.20047/j.issn1673-7210.2024.18.02.

[5]Chen X, Lin Z, Chen Y, et al.C-reactive protein/lymphocyte ratio as a prognostic biomarker in acute pancreatitis: A cross-sectional study assessing disease severity.[J].International journal of surgery (London, England), 2024,

[6]邹益，李泽宇，王红.PLR、NLR、MLR、RPR、CLR评估高脂血症性急性胰腺炎严重程度的临床意义[J].胃肠病学，2021，26（04）：218-222.

[7]Sahin A. Neutrophil-Creatinine Index: A New Prognostic Factor for Severity of Acute Pancreatitis.[J].Medicina (Kaunas, Lithuania), 2024, 60(4):607.

[8]缪淑贤，颜群，卢英，等.血清肌酐、尿素、尿酸和胱抑素C在肾功能损伤的诊断价值[J].江苏医药，2018，44（06）：661-663.DOI：10.19460/j.cnki.0253-3685.2018.06.018.

[9]Liu J, Bai Y, Aziguli A, Zhang YL. Value of neutrophil-monocyte product combined with serum creatinine in assessing the severity of acute pancreatitis[J]. Nan Fang Yi Ke Da Xue Xue Bao. 2017 Sep 20;37(9):1270-1273.DOI:10.3969/j.issn.1673-4254.2017.09.23.

[10]Chi Cheng, Zhou Ying, Song Xiaojing, et al. Establishment and diagnostic value of an early warning model for acute pancreatitis complicated with acute respiratory distress syndrome. Chin J Emerg Med, 2023, 32(8): 1046-1052.

[11]王博.Tim-4在巨噬细胞衰老中的作用研究[D].山东大学，2023.DOI：10.27272/d.cnki.gshdu.2023.005675.

[12]刘梦琪，周小明，张维宁.黏蛋白的结构与功能及其在肿瘤诊断治疗中的应用前景[J].江苏大学学报（医学版），2023，33（03）：270-276

[13]Min L, Jin H, Jian H, et al.Level of serum soluble Tim-3 expression in early-phase acute pancreatitis.[J].The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology, 2019, 30(2):188-191.

[14]Fushuang W, Minghui Z, Yao M, et al.Serum soluble T cell immunoglobulin mucin domain-3 as an early predictive marker for severity of acute pancreatitis; a retrospective analysis.[J].BMC gastroenterology, 2022, 22(1): 522-522.

[15]Kun Z, Jun Z, Rong Z Z, et al.Diagnostic and Prognostic Value of TAT, PIC, TM, and t-PAIC in Malignant Tumor Patients With Venous Thrombosis[J].Clinical and Applied Thrombosis/Hemostasis, 2020, 261076029620971041-1076029620971041.

[16]Huang K, Mo Q, Liao C, et al.The clinical significance of TAT, PIC, TM, and t-PAIC in vascular events of BCR/ABL-negative myeloproliferative neoplasms.[J].Clinical and experimental medicine, 2024, 24(1):107-107.

[17]Liao C, Liu G, Li L, et al.Predictive value of thrombin-antithrombin III complex and tissue plasminogen activator-inhibitor complex biomarkers in assessing the severity of early-stage acute pancreatitis.[J].Journal of gastroenterology and hepatology, 2024, 39(10):2088-2096.

[18]Adams JE 3rd, Bodor GS, Dávila-Román VG, et al. Cardiac troponin I. A marker with high specificity for cardiac injury. Circulation. 1993 Jul;88(1):101-6.

[19]Huang Junmin, Gong Xinyuan, Liu Tengfei, et al. The predictive value of emergency bedside echocardiography on acute pancreatitis severity by assessing cardiac dysfunction. Chin J Emerg Med, 2022, 31(1): 66-72.

[20]Bing Z, Silei S, Yihui W, et al.Cardiac indicator CK-MB might be a predictive marker for severity and organ failure development of acute pancreatitis.[J].Annals of translational medicine, 2021, 9(5):368-368.

[21]Morita K, Sasaki H, Furuse M, Tsukita S. Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol. 1999 Oct 4; 147(1): 185-94.

[22]Chen X, Wang H, Geng P, et al.[Serum Claudin-5 levels facilitate the early prediction of severe acute pancreatitis: a prospective observational study].[J].Zhonghua wei zhong bing ji jiu yi xue, 2024, 36(9):930-936.

[23]Xian-Ming X, Bang-Ku L, Shi-Mei X, et al.Emodin promoted pancreatic claudin-5 and occludin expression in experimental acute pancreatitis rats.[J].World journal of gastroenterology, 2012, 18(17):2132-9.

[24]Rim H, J C P, Ander C, et al.D-Dimer elevation and adverse outcomes.[J].Journal of thrombosis and thrombolysis, 2015, 39(1):55-9.

[25]M S B. D-dimer assays in diagnosis and management of thrombotic and bleeding disorders.[J].Seminars in thrombosis and hemostasis, 2012, 38(7):673-82.

[26]Dejan R, Djordje B, Nenad I, et al.D-dimer in acute pancreatitis: a new approach for an early assessment of organ failure.[J].Pancreas, 2009, 38(6):655-60.

[27]Newton V M. D-dimer as a Marker of Severity and Prognosis in Acute Pancreatitis.[J].International journal of applied & basic medical research, 2024, 14(2):101-107.


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