耐药性癫痫的研究进展

付 逍楚1, 王兰 桂*2
1、青海大学研究生院
2、青海大学附属医院神经内科

摘要


耐药性癫痫（drug-resistant epilepsy，DRE）是指经过合理的抗癫痫药物治疗后，仍无法控制发作的癫痫类型，给患者的生活质量和社会功能带来了极大影响。近年来，耐药性癫痫的研究取得了一定进展，尤其在病理机制、诊断方法和治疗策略方面。病理机制研究表明，离子通道异常、神经递质失衡、血脑屏障功能障碍及多药耐药基因的表达等因素均可能导致癫痫耐药性。针对诊断，影像学检查、生物标志物及临床评估工具的应用提升了耐药性癫痫的早期发现和准确评估。治疗策略方面，除传统的药物治疗外，手术治疗、神经调控技术及综合治疗方案等新兴疗法为耐药性癫痫的管理提供了新的选择。尽管如此，耐药性癫痫的治疗仍面临许多挑战，需要进一步的临床和基础研究以改善患者的预后。

关键词


耐药性癫痫；病理机制；诊断；治疗；影像学；神经调控技术

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参考


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