感染与炎症在早产发病中的研究进展

王 雨晴1, 王 妙英2
1、承德医学院
2、邯郸市中心医院

摘要


早产是全球新生儿死亡及并发症的首要原因,已成为全球性的公共卫生问题。早产的发病机制尚未完全明确。
现有证据表明感染与炎症反应是引发子宫收缩和胎膜早破的关键因素,因此其与早产的发生关系密切。本文从感染途
径、分子机制及炎症标志物三个方面系统综述感染、炎症与早产的关系,以期为早产的预测和防治策略提供理论依据。

关键词


感染;炎症;早产

全文:

PDF


参考


[1]Walani S R.Global burden of preterm birth[J].Int J

Gynaecol Obstet, 2020, 150(1):31-33.

[2]O E O, AnnBeth M, Ellen B, et al.National, regional,

and global estimates of preterm birth in 2020, with trends

from 2010: a systematic analysis.[J].Lancet (London, England),

2023, 402(10409):1261-1271.

[3]Prediction and Prevention of Spontaneous Preterm

Birth: ACOG Practice Bulletin Summary, Number 234[J].

Obstetrics & Gynecology, 2021, 138(2):320-323.

[4]孔北华,马丁,段涛.妇产科学[M].北京:人民

卫生出版社,2024:100.

[5]S L R, Sungjin K, Arum H, et al.Modeling ascending

infectionwith a feto-maternal interface organ-on-chip.[J].

Lab on a chip, 2020, 20(23):4486-4501.

[6]Gomez-Lopez N, Galaz J, Miller D. The

immunobiology of preterm labor and birth: intra-amniotic

inflammation or breakdown of maternal-fetal homeostasis.

Reproduction. 2022 Jun 20;164(2):R11-R45.

[7]Zhou Q, Yu Y, Zhou J, et al.Relationship of

Lactobacillus Vaginal Microbiota Changes and the Risk of

Preterm Birth: A Systematic Review and Meta-Analysis.[J].

Journal of women's health (2002), 2024, 33(2):228-238.

[8]邓洪,唐冬梅,魏璐,等.宫颈机能不全孕妇阴

道微生物菌群特征及其与早产的相关性研究[J].中国现代

医学杂志,2023,33(07):90-96.

[9]漆洪波,冉雨鑫.重视早产综合征的病因及发病

机制研究[J].中国实用妇科与产科杂志,2022,38(02):

134-137.[10]Bayar E, Bennett PR, Chan D, Sykes L, MacIntyre

DA. The pregnancy microbiome and preterm birth. Semin

Immunopathol. 2020;42(4):487-499.

[11]J D S, Nitan S, Kate W, et al.Gut pathogen

colonization precedes bloodstream infection in the neonatal

intensive care unit.[J].Science translational medicine, 2023,

15(694):eadg5562-eadg5562.

[12]Galaz J, Romero R, Xu Y, et al. Cellular immune

responses in amniotic fluid of women with preterm clinical

chorioamnionitis. Inflamm Res. 2020;69(2):203-216.

[13]Ott N, Faletti L, Heeg M, Andreani V, Grimbacher

B. JAKs and STATs from a Clinical Perspective: Loss-ofFunction Mutations, Gain-of-Function Mutations, and

Their Multidimensional Consequences. J Clin Immunol. 2023

Aug;43(6):1326-1359.

[14]魏丹,周永红,郭瑜,等.早产与炎症反应相关

机制的研究进展[J].中国医刊,2024,59(05):485-488.

[15]WOOD E M, HORNADAY K K, SLATER D

M. Prostaglandins in biofluids in pregnancy and labour: A

systematic review[J]. PLoS One, 2021, 16(11): e0260115.

[16]HERRERA C L, MAITI K, SMITH R. Preterm

birth and corticotrophin releasing hormone as a placental

clock[J]. Endocrinology, 2022, 164(2): bqac206.

[17]Tian Y, Zhang F, Qiu Y, et al. Reduction of

choroidal neovascularization via cleavable VEGF antibodies

conjugated to exosomes derived from regulatory T cells. Nat

Biomed Eng. 2021;5(9):968-982.

[18]Zhang X, Peng J, Yang Y, et al.Vascular

development analysis: a study for tertiary anti-vascular

endothelial growth factor therapy after second reactivation

of retinopathy of prematurity[J].Frontiers in Medicine, 2024,

11:1421894-1421894.

[19]Tita AT, Doherty L, Roberts JM, et al. Adverse

Maternal and Neonatal Outcomes in Indicated Compared

with Spontaneous Preterm Birth in Healthy Nulliparas: A

Secondary Analysis of a Randomized Trial. Am J Perinatol.

2018;35(7):624-631.

[20]McGowan EC, Vohr BR. Neurodevelopmental

Follow-up of Preterm Infants: What Is New?. Pediatr Clin

North Am. 2019;66(2):509-523.

[21]Crump C, Sundquist J, Sundquist K. Preterm

Delivery and Long-Term Risk of Stroke in Women:

A National Cohort and Cosibling Study. Circulation.

2021;143(21):2032-2044.

[22]Zierden HC, Shapiro RL, DeLong K, Carter DM,

Ensign LM. Next generation strategies for preventing preterm

birth. Adv Drug Deliv Rev. 2021;174:190-209.

[23]Ying C, Wen L, Yongmei S, et al.Association

between interleukin-6 and preterm birth: a meta-analysis.[J].

Annals of medicine, 2023, 55(2):2284384-2284384.

[24]Chen YS, Mirzakhani H, Knihtilä H, et al. The

Association of Prenatal C-Reactive Protein and Interleukin-8

Levels with Maternal Characteristics and Preterm Birth. Am J

Perinatol. 2024;41(S 01):e843-e852.

[25]王晶,陈维,王子莲.早产的预测[J].中国实用

妇科与产科志,2021,37(11):1095-1101.

[26]Marcellin L, Batteux F, Chouzenoux S, et

al.Second‐trimester amniotic fluid proteins changes in

subsequent spontaneous preterm birth[J].Acta Obstetricia et

Gynecologica Scandinavica, 2023, 102(5):597-604.

[27]Jiayi L, Jianrong G, Na R, et al.Finding the priority

and cluster of inflammatory biomarkers for infectious preterm

birth: a systematic review.[J].Journal of inflammation (London,

England), 2023, 20(1):25-25.

[28]Sina V, Parham T, Reza T, et al.The Association

of Inflammatory Biomarker of Neutrophil-to-Lymphocyte

Ratio with Spontaneous Preterm Delivery: A Systematic

Review and Meta-analysis.[J].Mediators of Inflammation,

2021, 2021:6668381.

[29]Alev E, Ismail D. Neutrophil/Lymphocyte and

Platelet/Lymphocyte Ratio in Preterm Premature Rupture of

Membranes.[J].Cureus, 2023, 15(5):e38664-e38664.

[30]Zhang J, Fan C, Xu C, et al.Serum calcium level

at 32 weeks of gestation could be applied as a predictor of

preterm delivery: a retrospective study[J].European Journal of

Medical Research, 2024, 29(1):400-400.

[31]Hrubaru I, Motoc A, Moise ML, et al. The

Predictive Role of Maternal Biological Markers and

Inflammatory Scores NLR, PLR, MLR, SII, and SIRI for the

Risk of Preterm Delivery. J Clin Med. 2022;11(23):6982.

[32]Uçkan K, Başkıran Y, Çeleğen İ. Association of

subclinical markers of inflammation with preterm premature

rupture of membranes and adverse neonatal results: a case

control study. Arch Gynecol Obstet. 2022;306(6):2063-2068.

[33]谢双华,阴赪宏.免疫炎症指数与早产的关系研

究进展[J].中国医刊,2024,59(12):1281-1283.


Refbacks

  • 当前没有refback。