mRNA转录组测序在OSAHS诊疗中的研究进展

秦 依沙1, 石 雪峰2
1、青海大学研究生院临床医学院
2、青海省人民医院

摘要


阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea-hypopnea syndrome，OSAHS）是一种复杂的睡眠障碍性疾病，其发病机制涉及间歇性低氧、睡眠碎片化、氧化应激与炎症反应等多方面因素，共同引发一系列复杂的病理生理改变。近年来，作为高通量测序技术的mRNA转录组测序，逐渐成为揭示基因表达变化及调控机制的重要工具。通过对OSAHS患者组织或细胞进行转录组学分析，能够全面解析疾病相关的基因表达谱，挖掘潜在的分子机制。随着转录组测序技术的迭代及人工智能分析的发展，mRNA转录组分析在OSAHS的早期诊断、个性化治疗方案制定、生物标志物筛选、治疗靶点探索及预后评估中展现出显著潜力。深入挖掘转录组数据，将为阐明OSAHS的病理生理过程提供更深刻的见解，推动该领域基础研究与临床实践的双重突破。

关键词


mRNA转录组测序；阻塞性睡眠呼吸暂停低通气综合征；生物标志物；基因表达分析

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参考


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