红细胞分布宽度与疾病关联的机制

钱 建平, 罗朋 立*
青海大学附属医院临床医学院

摘要


红细胞分布宽度（RDW）是一种全血细胞计数常规测量和自动生成的血液参数，是外周血中红细胞大小变异性和异质性的量度。RDW最初用于贫血原因的鉴别，近年来诸多研究发现RDW在评估疾病严重程度和临床结局方面具有临床意义。RDW的临床价值已在多种疾病中得到证实，包括心血管疾病、呼吸系统疾病、消化道疾病、肾功能不全、自身免疫性疾病、癌症、脓毒症等。RDW与疾病关联的可能病理生理机制包括炎症、氧化应激、神经内分泌和交感神经系统激活、衰老及营养代谢紊乱等。

关键词


红细胞分布宽度；炎症；氧化应激；肾功能不全；神经内分泌

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参考


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