弥散张量成像在OSAHS合并缺血性脑卒中患者认知功能的研究进展

李 唯扬1, 拜承 萍*2
1、青海大学研究生院
2、青海大学附属医院

摘要


阻塞性睡眠呼吸暂停低通气综合征（Obstructive Sleep Apnea-Hypopnea Syndrome，OSAHS）是由于睡眠时呼吸道阻塞，在睡眠期间频繁发生部分或完全通气中断，进而引起间歇性低氧血症和睡眠片段化。缺血性脑卒中，是由于脑部供血动脉发生狭窄、闭塞或血栓形成等病变，导致局部脑组织因血液供应中断而缺血、缺氧，进而引发神经元、胶质细胞等脑组织细胞坏死，并出现相应神经功能缺损的一类临床综合征。OSAHS已被确定为缺血性脑卒中的独立危险因素，两者相互影响，加速病情进展。弥散张量成像（diffusion tensor imaging，DTI）是目前唯一能观察脑白质纤维的无创方法，可以定性分析脑白质的微观结构，反映脑白质纤维的完整性和方向性。研究表明OSAHS合并缺血性脑卒中患者的认知功能损害为主要并发症之一，尤其是脑白质损害，DTI作为评估脑白质纤维束完整性的重要技术，为揭示认知功能损害机制提供了新视角。本文旨在梳理DTI在OSAHS合并缺血性脑卒中患者认知功能领域的研究进展。

关键词


弥散张量成像；阻塞性睡眠呼吸暂停低通气综合征；缺血性脑卒中；认知功能

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参考


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