DRP1在糖脂代谢中的研究进展

郝 紫苑1, 李志 红*2
1、承德医学院研究生学院;保定市第一中心医院
2、保定市第一中心医院

摘要


动力蛋白相关蛋白1（Dynamin related protein 1，DRP1）作为调控线粒体分裂的核心分子，在糖脂代谢紊乱中发挥关键作用。高糖高脂环境通过磷酸化修饰等机制异常激活DRP1，从而引起磷酸化，导致线粒体过度分裂、功能障碍及氧化应激，进而诱发胰岛素抵抗、胰岛β细胞损伤及脂代谢失调，推动2型糖尿病（T2DM）和高脂血症的发生发展。本文综述DRP1在糖脂代谢中的研究进展。

关键词


DRP1；2型糖尿病；高脂血症；糖脂代谢；胰岛素抵抗

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参考


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