单羟基咔咯的光物理性质及抗肿瘤活性研究

孙艳 梅*, 陈 若, 杨 佳玉, 施 洋, 陈 茵仪, 黄 榆枫
广东轻工职业技术大学

摘要


肝癌是全球主要癌症死因之一。光动力疗法（PDT）因全身副作用有限，在肝癌局部治疗中具有应用潜力，咔咯类化合物因其优异光物理化学特性成为极具潜力的光敏剂。本文选取3个单羟基取代自由咔咯，探究了其作为肝癌PDT新型光敏剂的光学特性、抗肿瘤活性及取代基位置效应。结果表明：取代基位置对咔咯光谱特征影响不显著；细胞毒性实验证实，3个单羟基咔咯均表现出优异PDT活性，且取代基位置会影响其毒性，其中对位羟基咔咯（p-OH）光毒性指数最高，PDT活性最优。本研究为开发基于单羟基咔咯的肝癌PDT新型光敏剂提供了实验依据。

关键词


单羟基咔咯；PDT；溶剂效应；细胞毒性

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参考


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