蛋白质精氨酸甲基转移酶与胰岛素抵抗相关性疾病

刘 细连1, 严 佳1, 蒋 明珺1, 陈亚 军*1, 钟 警2
1、南华大学附属第二医院
2、南华大学附属第一医院

摘要


胰岛素抵抗是2型糖尿病、肥胖、非酒精性脂肪肝、高血压及代谢综合征等代谢性疾病的核心病理特征。蛋白质精氨酸甲基转移酶作为广泛存在的翻译后修饰酶，在肿瘤、神经退行性疾病、心血管代谢疾病、肌肉疾病及炎症中发挥关键作用，但其在代谢功能中的角色尚未充分阐明。本综述旨在系统解析PRMTs在代谢功能中的特异性作用，揭示其作为代谢疾病治疗靶点的潜在价值。

关键词


PRMTs；胰岛素抵抗；代谢性疾病；表观遗传调控

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参考


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