高海拔地区阻塞性睡眠呼吸暂停低通气综合征对冠心病的研究进展

贾 文博1, 陈 礴*2
1、青海大学附属医院
2、青海省心脑血管专科医院

摘要


本文围绕高海拔地区阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与冠心病之间的关系展开系统综述，重点探讨了“OSAHS+高海拔”双重缺氧状态对冠心病发生发展的影响及其病理生理机制。文章指出，OSAHS在高海拔地区患病率更高，且其严重程度与冠状动脉病变程度呈正相关。双重缺氧通过激活交感神经系统、诱发氧化应激、炎症反应及内皮功能障碍等机制，加剧血压升高、血管损伤和血栓形成，从而促进冠心病的发生与进展。此外，本文还总结了针对此类患者的治疗策略，包括持续气道正压通气、氧疗、药物治疗及生活方式干预等，并展望了未来研究方向，如寻找新的药物靶点、开展长期随访研究及关注昼夜节律对睡眠与血压的影响。

关键词


阻塞性睡眠呼吸暂停低通气综合征（OSAHS）；高海拔；冠心病

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参考


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