ZFP36在恶性肿瘤中的研究进展

于 鹏杰, 张成 武*
青海大学附属医院肿瘤外科一（胃肠）

摘要


在细胞增殖、分化、迁移和凋亡过程中，转录后基因表达调控扮演着关键角色。越来越多的证据显示，癌症的重要发病机制是基因表达在转录后发生障碍。ZFP36（又称：TTP）是在基因表达的转录后调控中起关键作用的RNA结合蛋白TIS11家族成员之一。在机制上，这种蛋白质通过与非译区富集的AU元件结合在目标mRNA的3，端上发挥作用，从而对mRNA的调控产生影响。ZFP36是多种癌症相关生物过程的关键调节因子，在人类的许多癌症中都有不正常的表现。由于ZFP36具有抑制肿瘤的特性，还与肿瘤耐药、预后、转移、化疗等有一定的关联。在此，我们总结了被报道由ZFP36调控的癌症各种标志性分子特征，以及其在相关癌症类型/细胞系中调控相关mRNA靶点的作用。最后，我们强调了ZFP36作为预后指标的潜力，并讨论了针对ZFP36RNA结合蛋白以获得治疗益处的可能性。

关键词


转录后调控；RNA结合蛋白；肿瘤抑制；ZFP36

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参考


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