雌激素受体调控的杜鹃花—当归复合发酵液治疗大学生原发性痛经的研发与实践

于 慧瑶, 孟祥 云*
牡丹江医科大学

摘要


目的：研发一种通过雌激素受体（ER）调控的杜鹃花-当归复合发酵液（D-OF），并评估其治疗原发性痛经（PD）的有效性与安全性[1，2]。方法：采用ERα/ERβ报告基因系统评估D-OF的受体选择性；建立苯甲酸雌二醇联合缩宫素诱导的PD大鼠模型，观察扭体次数和潜伏期；开展随机、双盲、安慰剂对照临床试验（n=80），以视觉模拟评分（VAS）、月经失血量图（PBAC）评分及不良反应为主要指标[3，4]。结果：D-OF可选择性激活ERβ（最高激活率220±15%），而对ERα激活作用弱（110±10%）。动物实验中，D-OF高剂量组扭体次数较模型组减少68%（8±1次 vs 25±3次），潜伏期延长至450±40秒。临床试验显示，D-OF组VAS评分由7.5±1.2降至2.9±0.8（降幅61.3%），显著优于安慰剂组（6.0±1.0），有效率85%，且仅2例出现轻度胃肠道反应[5]。结论：D-OF可能通过选择性调控ERβ通路，安全有效地缓解原发性痛经[6，7]。

关键词


雌激素受体；杜鹃花；当归；原发性痛经；复合发酵液

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参考


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