儿童功能性便秘药物治疗现状及难治性影响因素的研究进展

廖 文龙, 王 刚祚
湖北民族大学附属恩施土家族苗族自治州中心医院

摘要


儿童功能性便秘是儿科常见的肠-脑互动障碍，单纯药物治疗后症状迁延及停药复发较为常见。本文综述常规导泻剂、微生态制剂及新型靶向药物治疗现状，从生理基线、饮食生活方式、神经心理共病、医患家庭管理维度分析该病难治与停药复发的影响因素。现有证据表明，聚乙二醇和乳果糖仍是解除嵌塞及维持治疗的基础用药，微生态制剂可作为辅助干预手段，新型促分泌药和促动力药是当前药物研发的重要方向，但传统治疗在长期无药缓解、依从性维持及规范撤药方面仍存不足。本文旨在为临床优化个体化治疗方案、规范撤药流程及加强长期管理提供参考。

关键词


儿童功能性便秘；药物治疗；微生态制剂；难治性因素

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参考


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