食管癌组织中CAF的表达及与临床预后的研究

田 春桃1, 张 冬1, 刘 颖2, 郭 宇2, 李 明阳3
1、三门峡市中心医院　肿瘤科
2、三门峡市中心医院　病理科，精准医学中心
3、空军军医大学　病理科

摘要


目的：探讨食管癌组织中肿瘤相关成纤维细胞（cancer associated fibroblast，CAF）的表达，分析其临床病理特征及与预后的关系。方法：采用免疫组织化学染色法检测CAF在食管癌组织中的表达；以α-SMA作为CAF的标记物，检测α-SMA的表达，分析其表达方式与临床病理特征的相关性；采用Kaplan-Meier方法进行生存分析。结果：α-SMA在食管癌组织中的表达与食管癌浸润深度、淋巴结转移、TNM分期相关（P<0.05），α-SMA高表达者预后不良。结论：CAF影响食管癌的疾病进展及预后，检测其表达可能作为食管癌新的预后指标和治疗靶点。

关键词


食管癌；α-SMA；预后

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参考


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