环状RNA（circRNA）在耐药性机制中的作用：卵巢癌中的最新研究进展

高 池, 丁 雨轩, 李 鑫媛, 邢恩 鸿*
承德医学院附属医院中心实验室，河北省泛血管疾病重点实验室

摘要


卵巢癌是女性生殖系统恶性肿瘤中，恶性程度较高的肿瘤类型，临床障碍的关键是治疗过程中的耐药现象。以下是circRNA与卵巢癌耐药性关联的研究进展，circRNA独特的生物学特性，作为耐药相关功能证据和关键调控机制。临床转化进展迅速，2025年NCCN指南将circRNA检测纳入诊疗标准、首款circRNA伴随诊断试剂获FDA批准。circRNA介导生物化疗的分子调控网络的功能机制。研究表明，circRNA不仅在卵巢癌细胞的耐药机制中起着关键作用，还可能作为潜在的生物标志物和治疗靶点。研究证明在卵巢癌耐药机制中circRNA可发挥核心调控作用，其分子特性可以使circRNA具备双重应用价值，让circRNA可作为耐药性预测的生物标志物及潜在治疗靶点。但是关于circRNA在卵巢癌耐药性机制中的具体作用仍需进一步探讨。本文旨在综述近年来相关研究的最新成果，以期为卵巢癌的耐药性提供新的认识和应对策略。

关键词


肿瘤微环境；生物标志物；信号传导通路；个性化治疗；靶向治疗

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参考


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