胃癌组织THBS2和Ki-67表达与临床病理特征及预后的关系

魏 洁, 杜 兴龙, 代 元飞, 薛 松, 何 广思
安徽医科大学附属滁州医院/滁州市第一人民医院肿瘤科

摘要


目的：分析THBS2和Ki-67蛋白在胃癌中的表达及其与临床病理特征和预后的关系。方法：选取2017年1月-2020年12月在安徽医科大学附属滁州医院胃肠外科行胃癌根治性手术的93例患者手术切除标本，采用免疫组化检测THBS2与Ki-67在胃癌及癌旁组织的表达，分析THBS2与Ki-67表达与患者临床病理特征的关系及两者表达的相关性，进一步采用单因素和多因素分析两者对预后影响。结果：THBS2与Ki-67在胃癌组织中的表达高于癌旁组织，两者在胃癌患者中的表达与淋巴结转移、TNM分期相关，而与性别、年龄、肿瘤大小、组织学分级、T分期无关。THBS2与Ki-67表达呈正相关关系。单因素分析显示：淋巴结转移、TNM分期、THBS2表达、Ki-67表达是胃癌患者总生存的影响因素；多因素分析显示：TNM分期及双高表达（THBS2高表达+Ki-67高表达）为胃癌患者预后的独立危险因素。结论：THBS2与Ki-67高表达均与预后不良有关，联合检测有助于更好判断预后。

关键词


胃癌；THBS2；Ki-67；预后

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参考


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