乳腺癌中巨噬细胞调控与天然成分干预研究

刘 洮荣1, 梁 俊青2
1、内蒙古医科大学研究生院
2、北京大学肿瘤医院内蒙古医院/内蒙古医科大学附属肿瘤医院乳腺中心

摘要


肿瘤相关巨噬细胞（TAMs）是驱动乳腺癌转移的核心。本文梳理了TAMs通过微环境募集、M2极化、上
皮-间质转化及基质重塑等促转移机制。针对常规靶向治疗的局限，重点综述天然成分与中蒙药多靶点调控TAMs
表型的进展。其低毒性与整体调节优势，为乳腺癌抗转移新疗法提供了理论及转化思路。

关键词


乳腺癌转移；肿瘤相关巨噬细胞；肿瘤微环境；靶向治疗；天然药物

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参考


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