可溶性微针结合纳米粒在皮肤病中的研究进展

姚 菲
烟台大学

摘要


本文全面综述了可溶性微针结合纳米粒在皮肤病治疗领域的研究进展。阐述了该联合技术在透皮给药方面
相较于传统方式的显著优势,详细介绍了其在多种常见皮肤病如银屑病、皮肤癌、特异性皮炎等治疗中的应用,分析
了当前技术面临的挑战,并对未来发展趋势进行了展望,旨在为皮肤病治疗领域的进一步研究和临床应用提供参考。

关键词


可溶性微针;纳米粒;银屑病;皮肤癌;特异性皮炎

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参考


[1]Kenchegowda M, Hani U, Al Fatease A, et al.

Tiny titans-unravelling the potential of polysaccharides and

proteins based dissolving microneedles in drug delivery and

theranostics: a comprehensive review[J]. International Journal

of Biological Macromolecules, 2023, 253: 127172.

[2]ESMO Guidelines Committee. Cutaneous melanoma:

ESMO Clinical Practice Guideline for diagnosis, treatment

and follow-up[J]. Annals of Oncology, 2025, 36(1): 10-30.

[3]Wu C, Yu Q, Huang C, et al. Microneedles as

transdermal drug delivery system for enhancing skin disease

treatment[J]. Acta Pharmaceutica Sinica B, 2024, 14(12):

5161-5180.

[4]Lv X, Xiang C, Zheng Y, et al. Recent developments

in using microneedle patch technology as a more efficient

drug delivery system for treating skin photoaging[J]. Clinical,

Cosmetic and Investigational Dermatology, 2024: 2417-2426.

[5]Feng S, Yang L, Wen D, et al. A transdermal delivery

system using microneedle patches containing poly (lacticco-glycolic)-encapsulated acitretin nanoparticles for topical

and extended treatment[J]. International Biodeterioration &

Biodegradation, 2024, 195: 105906.

[6]Zeng Y, Wu L, Jiang X, et al. Self-assembled hyaluronic

acid nanoparticles delivered by polymeric microneedles for

targeted and long-acting therapy of psoriasis[J]. International

Journal of Pharmaceutics, 2025, 669: 125073.

[7]Li J, Yuan Z, Shi S, et al. Microneedle patches

incorporating zinc-doped mesoporous silica nanoparticles

loaded with betamethasone dipropionate for psoriasis

treatment[J]. Journal of Nanobiotechnology, 2024, 22(1): 706.

[8]Zhou Y, Yang L, Lyu Y, et al. Topical delivery

of ROS-responsive methotrexate prodrug nanoassemblies

by a dissolvable microneedle patch for psoriasis therapy[J].

International Journal of Nanomedicine, 2023: 899-915.

[9]Dai X, Permana A D, Li M, et al. Calcipotriol

nanosuspension-loaded trilayer dissolving microneedle

patches for the treatment of psoriasis: in vitro delivery and in

vivo antipsoriatic activity studies[J]. Molecular Pharmaceutics,

2024, 21(6): 2813-2827.

[10]Hao Y, Chen Y W, He X L, et al. Near-infrared

responsive 5-fluorouracil and indocyanine green loaded MPEGPCL nanoparticle integrated with dissolvable microneedle for

skin cancer therapy[J]. Bioactive Materials, 2020, 5(3): 542-552.

[11]Li Y, Ye Z, Ye H, et al. Chondroitin sulfate-based

dissolvable microneedles loaded with NIR-II photothermal and

natural anticancer agents for synergistic melanoma therapy[J].

International Journal of Biological Macromolecules, 2025, 300:

140223.

[12]Zhao Y, Zhou Y, Yang D, et al. Intelligentand spatiotemporal drug release based on multifunctional

nanoparticle-integrated dissolving microneedle system

for synergetic chemo-photothermal therapy to eradicate

melanoma[J]. Acta Biomaterialia, 2021, 135: 164-178.

[13]Liu P, Hao L, Hsu J C, et al. Biomineralized

Nanocomposite‐Integrated Microneedle Patch for Combined

Brachytherapy and Photothermal Therapy in Postoperative

Melanoma Recurrence and Infectious Wound Healing[J].

Advanced Science, 2025, 12(12): 2414468.

[14]Pu X Q, Ju X J, Liu W Y, et al. Stimulus-responsive

nanoparticle-integrated dissolving microneedles for synergetic

chemo-photothermal therapy of superficial skin tumors[J].

Industrial & Engineering Chemistry Research, 2022, 61(23):

7982-7995.

[15]Li P, Liu C H, Zhao Y Y, et al. Multifunctional

covalent organic framework-based microneedle patch for

melanoma treatment[J]. Biomacromolecules, 2023, 24(8):

3846-3857.

[16]Qin W, Quan G, Sun Y, et al. Dissolving

microneedles with spatiotemporally controlled pulsatile release

nanosystem for synergistic chemo-photothermal therapy of

melanoma[J]. Theranostics, 2020, 10(18): 8179.

[17]Li Y, Gong J Y, Wang P, et al. Dissolving

microneedle system containing Ag nanoparticle-decorated silk

fibroin microspheres and antibiotics for synergistic therapy of

bacterial biofilm infection[J]. Journal of Colloid and Interface

Science, 2024, 661: 123-138.

[18]Permana A D, Mir M, Utomo E, et al. Bacterially

sensitive nanoparticle-based dissolving microneedles of

doxycycline for enhanced treatment of bacterial biofilm skin

infection: A proof of concept study[J]. International journal of

pharmaceutics: X, 2020, 2: 100047.

[19]Zhang W, Lei J, Jiang P, et al. Double‐Layered

Microneedle Patch Integrated with Multifunctional

Nanoparticles and Live Bacteria for Long‐Term Treatment of

Atopic Dermatitis[J]. Small, 2025, 21(3): 2409121.

[20]Wu T, Hou X, Li J, et al. Microneedle-mediated

biomimetic cyclodextrin metal organic frameworks for active

targeting and treatment of hypertrophic scars[J]. Acs Nano,

2021, 15(12): 20087-20104.

[21]Wang M, Han Y, Yu X, et al. Upconversion

nanoparticle powered microneedle patches for transdermal

delivery of siRNA[J]. Advanced healthcare materials, 2020,

9(2): 1900635.


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