外泌体与皮肤靶向作用机制及化妆品应用研究进展

吴 亚蜜
烟台大学

摘要


外泌体作为直径30-150nm的天然纳米囊泡，通过蛋白质、脂质与核酸的协同递送，在皮肤稳态调控中展现
出多靶点干预潜力。动物源性外泌体以磷脂酰胆碱为主膜成分，依赖整合素介导的内吞激活PI3K/AKT-mTORC1
通路，促进成纤维细胞胶原合成；植物源性外泌体则凭借鞘磷脂富集及3'端甲基化修饰的miRNA，经SIRT1-PGC-
1α轴抑制线粒体氧化应激，兼具高安全性与规模化优势。临床研究表明，外泌体在抗光老化、美白及屏障修复领域
功效显著，但异质性控制与监管滞后仍是产业化瓶颈。本文系统梳理外泌体的结构特征、皮肤靶向机制及化妆品应
用现状，为精准护肤产品开发提供理论参考。

关键词


动物外泌体；植物外泌体；化妆品；皮肤靶向；抗衰老

全文:

PDF


参考


[1]Bielach-Bazyluk A, Zbroch E, Mysliwiec H, et al.

Sirtuin 1 and skin: implications in intrinsic and extrinsic aging— a systematic review[J]. Cells, 2021, 10(4): 813.

[2]Pan Q, Bao Z, Wang Y, et al. RETRACTED: Nrf2

pathway activation with natural plant-derived exosomelike nanovesicle/hydrogel preparations for oxidative stress

modulation in inflammation related diseases[J]. 2024.

[3]Liu R, Zhang F, He X, et al. Plant derived ExosomeLike nanoparticles and their therapeutic applications in

glucolipid metabolism diseases[J]. Journal of Agricultural and

Food Chemistry, 2025, 73(11): 6385-6399.

[4]Sun L, Chiang JY, Choi JY, et al. Transient induction

of telomerase expression mediates senescence and reduces

tumorigenesis in primary fibroblasts[J]. Proceedings of the

National Academy of Sciences, 2019, 116(38): 18983-18993.

[5]Bielach-Bazyluk A, Zbroch E, Mysliwiec H, et al.

Sirtuin 1 and skin: implications in intrinsic and extrinsic aging

— a systematic review[J]. Cells, 2021, 10(4): 813.

[6]Mohamad EA, Aly AA, Khalaf AA, et al. Evaluation

of Natural Bioactive-Derived Punicalagin Niosomes in SkinAging Processes Accelerated by Oxidant and Ultraviolet

Radiation[J]. Drug Design, Development and Therapy, 2023,

17: 807-808.

[7]Meng X, Guo M, Geng Z, et al. Effects and

mechanism of the Leontopodium alpinum callus culture

extract on blue light damage in human foreskin fibroblasts[J].

Molecules, 2023, 28(5): 2172.

[8]Kim J, Li S, Zhang S, et al. Plant-derived exosomelike nanoparticles and their therapeutic activities[J]. Asian

journal of pharmaceutical sciences, 2022, 17(1): 53-69.

[9]Liu JK. Natural products in cosmetics[J]. Natural

products and bioprospecting, 2022, 12(1): 40.

[10]Liu HM, Cheng MY, Xun MH, et al. Possible

mechanisms of oxidative stress-induced skin cellular

senescence, inflammation, and cancer and the therapeutic

potential of plant polyphenols[J]. International Journal of

Molecular Sciences, 2023, 24(4): 3755.

[11]Cho JH, Hong YD, Kim D, et al. Confirmation

of plant-derived exosomes as bioactive substances for skin

application through comparative analysis of keratinocyte

transcriptome[J]. Applied Biological Chemistry, 2022, 65(1): 8.

[12]Wang L, Liu Z, Du X, et al. Construction and

evaluation of transdermal delivery system of terbinafineloaded plant exosomes for the treatment of cutaneous

fungal infections[J]. Journal of Drug Delivery Science and

Technology, 2024, 102: 106365.


Refbacks

  • 当前没有refback。