长链非编码RNA在糖尿病肾病中的研究进展

张 国庆
宁夏回族自治区人民医院肾内科 宁夏医科大学附属第三临床医学院

摘要


糖尿病肾病(DN)是糖尿病最常见的微血管并发症,已成为引起终末期肾病的主要病因。DN发病机制极
为复杂,涉及多种病理生理过程。越来越多的证据显示,不仅多种经典的信号通路参与DN足细胞损伤过程的调控,
而且表观遗传机制亦对足细胞损伤产生显著影响。近几年研究结果显示,长链非编码RNA(lncRNAs)在DN的发
病机制中发挥重要作用,lncRNAs广泛参与肾脏功能行使以及肾脏发育,在诊断方面显示出重要价值。

关键词


糖尿病肾病;足细胞损伤;长链非编码RNA;生物标志物;治疗靶点

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