MEKK2在脓毒症临床诊断与治疗中的研究新进展
摘要
护病房（ICU）患者死亡的主要原因之一。丝裂原活化蛋白激酶2（MEKK2）作为MAPK信号通路的关键调控分子，
在免疫细胞活化、炎症因子释放及血管内皮功能调节中发挥重要作用。近年来，随着对脓毒症病理机制研究的深入，
MEKK2在脓毒症发生发展中的调控作用逐渐被揭示，其在临床诊断标志物筛选及靶向治疗中的潜力备受关注。本文
系统梳理了脓毒症的定义与流行病学背景、MEKK2的生物学功能，结合国内外研究现状，重点分析MEKK2在脓毒
症中的分子机制、诊断价值及治疗靶点潜力，并对未来研究方向进行展望。
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