围术期星状神经节阻滞降低免疫应激 及改善睡眠障碍的研究进展
摘要
免疫-内分泌网络，发挥多效性治疗作用。在免疫调节方面，SGB可抑制促炎因子（如TNF-α、IL-6）释放，调
节淋巴细胞和自然杀伤细胞活性，并通过胆碱能抗炎通路及TLR4/NF-κB信号通路减轻炎症反应，促进术后恢复。
在睡眠改善方面，SGB通过抑制交感神经过度兴奋、调节褪黑素节律，有效提升术后睡眠质量，减少睡眠障碍发生
率。文章进一步指出，围术期免疫应激与睡眠障碍相互影响，形成恶性循环，而SGB通过综合调控应激与炎症反应，
打破该循环，具有广阔的临床应用前景。尽管现有研究显示SGB效果显著，仍需更多高质量随机对照试验以明确其
机制、优化治疗方案并评估长期疗效。
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