ATF5在乳腺癌中的临床意义与研究

李 曹月1, 张 金库2
1、承德医学院　研究生学院
2、保定市第一中心医院　病理科

摘要


激活转录因子5（ATF5）是激活转录因子/环磷腺苷效应元件结合蛋白（ATF/CREB）家族的成员，其特
征是包含一个碱性亮氨酸拉链（bZIP）结构域。ATF5在调控细胞应对内质网应激、氨基酸剥夺等压力中起核心作
用，通过促进促存活基因的表达来维持细胞稳态。ATF5参与细胞增殖、凋亡、分化和炎症相关病理过程，作为信号
转导网络的信息整合者之一，可介导细胞质热休克反应、未折叠蛋白反应等，调控肿瘤细胞中的各种压力刺激，介
导细胞的增殖或凋亡，而这些途径的级联效应与肿瘤的生长、侵袭转移密切相关；在乳腺癌中，ATF5呈现高表达，
使其从应激适应因子转变为强大的致癌驱动因子。本综述系统阐述了ATF5在乳腺癌中的表达模式、生物学功能、分
子作用机制、临床预后价值，并深入探讨了其作为新型诊断生物标志物和治疗靶点的巨大潜力。对ATF5的深入研究
将为乳腺癌的精准治疗提供新的理论和实践依据。

关键词


ATF5；乳腺癌；生物标志物；治疗靶点；凋亡抵抗；肿瘤干细胞

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