药物联合递送策略在克服肿瘤多药耐药中的研究进展

贾 玉涛1, 高 佳丽1, 常 明1, 吴 江立2
1、石家庄学院化工学院
2、河北中医药大学科研中心

摘要


癌细胞对一种或多种化疗药物产生耐药性的不同机制被称为多药耐药（MDR）。目前 MDR 已经成为癌症化疗失败的主要
原因，克服 MDR 一个重要的基本策略即是药物联合递送，包括小分子药物联用、药物与基因联用、不同类型基因联用以及药物
与加强辅助手段联用等几类。本文对近年来基于纳米载体的药物联合给药系统在对抗 MDR 中的应用进行详细介绍和总结，为相
关研究的开展提供了有意义的参考。

关键词


多药耐药 ；药物联合递送 ；纳米药物递送系统 ；化疗

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