传统中药钩藤活性生物碱对帕金森病的作用

黄 玉菊
山东医学高等专科学校

摘要


随着人口老龄化的加剧，帕金森病作为重要的神经退行性疾病，其预防和治疗越来越受到关注。据研究，中药钩藤作
为一种常用的中药，它对神经退行性疾病具有有效的神经保护作用。本文综述了钩藤中有效成分钩藤碱、异钩藤碱、柯诺辛碱
和柯诺辛碱 B 等有效成分对帕金森的作用，文章不仅为帕金森的防治提供了概述，也为中药新药的开发提供了展望。

关键词


中药 ；钩藤 ；生物碱 ；帕金森病

全文:

PDF


参考


[1]Parkinson, J., An essay on the shaking palsy. 1817.

J Neuropsychiatry Clin Neurosci, 2002.14(2):p.223-36;

discussion 222.

[2]Hayes, M.T., Parkinson's Disease and Parkinsonism.

Am J Med, 2019.132(7): p. 802-807.

[3]Goldman, S.M., et al., Concordance for Parkinson's

disease in twins: A 20-year update. Ann Neurol, 2019.

85(4):p. 600-605.

[4]Goldman,S.M., Environmental toxins and

Parkinson's disease.Annu Rev Pharmacol Toxicol,2014.

54:p.141-64.

[5]Twelves,D.,K.S. Perkins,and C.Counsell, Systematic

review of incidence studies of Parkinson's disease. Mov

Disord, 2003.18(1): p.19-31.

[6]Marras, C., et al., Prevalence of Parkinson's disease

across North America. NPJ Parkinsons Dis, 2018. 4: p. 21.

[7]Pinter, B., et al., Mortality in Parkinson's disease: a

38-year follow-up study. Mov Disord, 2015.30(2): p.266-

9.

[8]Shim, J.S., et al.,Effects of the hook of Uncaria

rhynchophylla on neurotoxicity in the 6-hydroxydopamine

model of Parkinson's disease.J Ethnopharmacol,2009.126(2):

p.361-5.

[9] 郑丽 , 王浩 , 巴寅颖 , 等 . 荜茇总生物碱对 6-

羟基多巴胺致帕金森病大鼠多巴胺能神经元损伤的保护

作用研究 [J]. 中国中药杂志 ,2014,39(09):1660-1665.

[10]Zhang, C., et al., Rhynchophylline alleviates

neuroinflammation and regulates metabolic disorders in a

mouse model of Parkinson's disease. Food Funct,2023.14(7):

p. 3208-3219.

[11]Lin, H., et al., Intranasally administered

thermosensitive gel for brain-targeted delivery of

rhynchophylline to treat Parkinson's disease. Colloids Surf B

Biointerfaces, 2023. 222: p.113065.

[12]Li, X., et al., [Antioxidant mechanism of gastrodin

combined with isorhynchophylline in inhibiting MPP~+-

induced apoptosis of PC12 cells]. Zhongguo Zhong Yao Za

Zhi, 2021.46(2): p.420-425.

[13]Chen, L.,et al., Corynoxine Protects Dopaminergic

Neurons Through Inducing Autophagy and Diminishing

Neuroinflammation in Rotenone-Induced Animal Models

of Parkinson's Disease.Front Pharmacol, 2021.12: p. 642900.

[14] 孙婷 . 新结构化合物生物碱异黄酮 LY01 和外

泌体抗帕金森病的疗效及分子机制研究 [D]. 中央民族

大学 ,2021.

[15]Zhu, Q., et al., Corynoxine B targets at HMGB1/2

to enhance autophagy for α-synuclein clearance in fly and

rodent models of Parkinson's disease. Acta Pharm Sin B,

2023.13(6): p. 2701-2714.


Refbacks

  • 当前没有refback。