褪黑素在慢性疼痛中的研究机制

乔 玲俐, 葛 永祺, 辜 苏, 刘 玲, 王 柏军
湖北科技学院药学院

摘要


褪黑素(melatonin，MT)是一种主要由松果体分泌的激素，具有抗氧化、抗肿瘤、镇静催眠以及调节昼夜节律的作用。褪黑素通过调节昼夜节律以其剂量依赖性发挥镇痛作用，同时与褪黑素受体，阿片类受体，中枢苯二氮卓类受体相互作用也可缓解疼痛。故本文将对褪黑素在慢性疼痛中的研究机制做一简要概述，并对褪黑素在后续研究中的应用前景与关键问题进行展望。

关键词


褪黑素；慢性炎症痛；癌性疼痛；神经病理性疼痛

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参考


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